Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10362Conference ProceedingsThe impact on the quality of life of various pharmacotherapy options for vitamin B12 deficiency in people with type 2 diabetes mellitus using metforminKorolevaIrina<p>graduate student&nbsp;of the Department of Medical and Social Assessment, Emergency, and Ambulatory Practice, Sechenov First Moscow State Medical University</p>koroleva_i_g@staff.sechenov.ruhttps://orcid.org/0000-0001-9758-1259SizovaZhanna<p>Doctor of medical sciences, Professor, Head of the Department of Medical and Social Assessment, Emergency, and Ambulatory Practice, Sechenov First Moscow State Medical University</p>sizova_zh_m@staff.sechenov.ruhttps://orcid.org/0000-0002-1242-7074ShikhEugenia<p>Doctor of medical sciences, Professor, Head of the Department of Clinical Pharmacology and Propedeutics of Internal Diseases, Sechenov First Moscow State Medical University</p>shikh_e_v@staff.sechenov.ruhttps://orcid.org/0000-0001-6589-7654Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University)2504202514S14854872402202524032025Copyright © 2025, Koroleva I., Sizova Z., Shikh E.2025<p>Currently, there is no gold standard for the choice of dose and method of administration (intramuscular, oral, sublingual, intranasal) of vitamin B12 (VB12) in the case of vitamin B12 deficiency. In 2022, the Expert Council of the Russian Scientific Expert Council of the Russian Scientific Medical Society of Therapists (RSMOT) adopted a resolution on the need to develop and introduce into practice a clear algorithm for the management of patients with established VB12 deficiency. Objective. Comparison of the dynamics of patients' life quality by treatment groups depending on the applied schemes of pharmacocorrection of VB12 deficiency. Materials and methods. Assessment of the quality of life before and after treatment using the EQ-5D questionnaire. Results. Among the patients the most significant dynamics was noted in Mobility and Pain/discomfort, especially in groups 1 and 3, taking metformin daily orally and intramuscularly, respectively. There were no significant changes in Self-care and Anxiety/depression qualities. The subjective state of health of patients increased most significantly in groups 1 and 3. Conclusion. The greatest positive effect on the patients' quality of life was observed with daily oral intake of 1 mg of cyanocobalamin for 8 weeks and daily intramuscular injection of 0.5 mg during the 1st week and then 500 mcg once a week for 16 weeks; weekly oral administration of 1 mg cyanocobalamin for 16 weeks resulted in 2-3 times less pronounced subjective improvement of quality of life.</p>metformincyanocobalaminvitamin B12 deficiencytype 2 diabetes mellituslife qualityметформинцианокобаламиндефицит витамина В12сахарный диабет 2-го типакачество жизни1.Obeid R, Andrès E, Češka R, Hooshmand B, Guéant-Rodriguez RM, Prada GI, Sławek J, Traykov L, Ta Van B, Várkonyi T, Reiners K, The Vitamin B Consensus Panelists Group. Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus. J Clin Med. 2024 Apr 10;13(8):2176. doi: 10.3390/jcm13082176. PMID: 38673453; PMCID: PMC11050313.2.Batulwar PS, Anjankar A. Individuals Diagnosed With Type 2 Diabetes Mellitus and the Status of Vitamin B12 Deficiency: A Review. Cureus. 2024 Feb 27;16(2):e55103. doi: 10.7759/cureus.55103. PMID: 38558585; PMCID: PMC10978817.3.Medicines and Healthcare Products Regulatory Agency . London: Medicines and Healthcare Products Regulatory Agency; 2022. Metformin and reduced vitamin B12 levels: new advice for monitoring patients at risk [Internet] [cited 2024 May 22]. Available from: https://bit.ly/3BlGkhJ.4.National Institute for Health and Care Excellence . Manchester: National Institute for Health and Care Excellence; 2024. Vitamin B12 deficiency in over 16s: diagnosis and management (NICE Guideline NG239) [Internet] [cited 2024 May 22]. Available from: https://www.nice.org.uk/guidance/ng239.5.Болиева Л.З., Болотина Л.В., Галстян Г.Р., Драпкина О.М., Екушева Е.В., Каприн А.Д., Лукина Е.А., Малявин А.Г., Мартынов А.И., Пономарев Р.В., Супонева Н.А., Тарасова Л.В. Резолюция Совета экспертов «Недостаточность/дефицит витамина В12 в клинической практике». Терапия. 2023; №1: 116-121. DOI: https://dx.doi.org/10.18565/therapy.2023.1.116-121.