Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10311Conference ProceedingsThe role of genetic factors in the development of dental caries: hereditary predisposition and other causes of occurrenceHamdanIosif M.<p>3rd year student of the faculty of dentistry</p>youseffcb333@gmail.comhttps://orcid.org/0009-0008-3478-0662BabenkoElena A.<p>4th year student of the faculty of dentistry</p>lena.babenko.03@mail.ruhttps://orcid.org/0009-0004-1325-8454VusatayaElena Vladimirovna<p>Cand. Sci. (Med.), Associate Professor of the Department of therapeutic dentistry</p>lena-elena099@mail.ruhttps://orcid.org/0000-0002-5057-5545Voronezh State Medical University named after N. N. Burdenko2504202514S17807832102202511032025Copyright © 2025, Hamdan I.M., Babenko E.A., Vusataya E.V.2025<p>Abstract.</p> <p>Introduction. Dental caries, despite advances in modern dentistry, remains one of the most common human diseases, affecting the vast majority of the world's population. While the role of external factors such as diet, oral hygiene and microflora composition is well studied and recognised, the influence of genetic factors on caries development is often underestimated. This study aims to investigate the role of genetic factors in the development of dental caries, examining both inherited predisposition and the interaction of genes with environmental factors.The study will analyse current data on genes associated with various aspects of the cariesogenic process, including enamel formation, saliva composition and quantity, and immune response to oral microflora. Particular attention will be paid to the relationship between genotype and phenotype in the context of caries development, as well as the prospects for the application of genetic information to develop personalised strategies for the prevention and treatment of this disease.The aim of this paper is to systematise the available knowledge on the genetic determinants of dental caries and to assess their contribution to the overall picture of the etiology and pathogenesis of this disease.</p>dental cariesgenetic factorshereditary predispositionenamel formationsaliva composition and quantityкариес зубовгенетические факторынаследственная предрасположенностьформирование эмалисостав и количество слюны1.1. Вязникова, Д. А., et al. "ПОЛИМОРФНЫЕ ВАРИАНТЫ ГЕНА ЛАКТОТРАНСФЕРРИНА (LTF) И ИХ ВЛИЯНИЕ НА РАЗВИТИЕ КАРИЕСА ЗУБОВ (ОБЗОР ГЕНЕТИЧЕСКИХ БАЗ ДАННЫХ DBSNP, ALFRED)." CETERIS PARIBUS 1 (2023): 20-22.2.2. Марковский, А. В. "МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ПРЕДПОСЫЛКИ КАРИЕСА ЗУБОВ." Актуальные проблемы патофизиологии. 2022.3.3. Чагина, Е. А., et al. "РОТОВАЯ ЖИДКОСТЬ КАК ФАКТОР РИСКА РАЗВИТИЯ КАРИЕСА." Международный журнал гуманитарных и естественных наук 3-3 (90) (2024): 121-124.4.4. Telatar G, Ermiş B. Çürük riski ve genetik. J Dent Fac Atatürk Uni. (2019) 29(2):350–6. doi: 10.17567/ataunidfd.2893465.5. Стешова, В. В., and Т. Ю. Ширяк. "ГЕНЕТИЧЕСКИЕ АСПЕКТЫ РАЗВИТИЯ КАРИЕСА ЗУБОВ." ББК 56.6 А 43 (2021): 140.6.6. Alotaibi RN, Howe BJ, Chernus JM, Mukhopadhyay N, Sanchez C, Deleyiannis FWB, et al. Genome-Wide Association Study (GWAS) of dental caries in diverse populations. BMC Oral Health. (2021) 21(1):1–11. doi: 10.1186/s12903-021-01670-57.7. Rathee M, Sapra A. Dental caries. Treasure Island (FL): StatPearls (2022). https://www.ncbi.nlm.nih.gov/books/NBK551699/8.8. Jouhar, Rizwan, et al. "Association of BMI, diet, physical activity, and oral hygiene practices with DMFT index of male dental students at King Faisal University, Al-Ahsa." Nutrients 13.1 (2021): 224.9.9. Gorji, Nadia Elyassi, et al. "Relationship between DMFT index and number of pregnancies: a cross-sectional study on enrollment phase of the Tabari Cohort Study." BMC Oral Health 21.1 (2021): 643.