Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10304Conference ProceedingsNa-Ca metabolism plays a leading role in the mechanism of cardiac ventricular fibrillation.RomankovaTatyana Alekseevnaromankovatana624@gmail.comhttps://orcid.org/0009-0001-3271-6797AlabovskyVladimir Vladimirovichkld@vrngmu.ruhttps://orcid.org/0000-0002-6306-5149VinokurovAlexey Anatolievichkld@vrngmu.ruhttps://orcid.org/0000-0003-0677-4739AlabovskyAlksey Vladimirovichmr.alabovskiy@mail.ruhttps://orcid.org/0009-0005-6464-5902KryukovaAnna Andreevnaanna.kryukova2004@gmail.comhttps://orcid.org/0009-0002-2422-2911VisangireevnaAminat Visangireevnaamina.amina06@inbox.ruhttps://orcid.org/0009-0007-7788-7227Voronezh State Medical University named after. N.N. Burdenko2504202514S159642102202530032025Copyright © 2025, Romankova T.A., Alabovsky V.V., Vinokurov A.A., Alabovsky A.V., Kryukova A.A., Visangireevna A.V.2025<p>The role of calcium in the occurrence of ventricular fibrillation is well known. The main role in this pathology is attributed to slow calcium channels, which are able to increase the intracellular concentration of calcium ions and thereby cause oscillations of membrane potential</p>
<p>However, there is evidence for the involvement of Na-Ca exchange, in the occurrence of arrhythmias. The question of the predominant involvement of these two different mechanisms in the occurrence of fibrillation remains to be elucidated. In this connection, the task of the present study was to establish the leading role of one of the two pathogenetic processes.</p>
<p>In experiments, on isolated hearts of white rats, the flow of calcium ions inside cardiomyocytes was activated by Na-Ca exchange. This produced ventricular fibrillation of the heart. After addition of a selective inhibitor of slow calcium channels (isoptin) to the perfusion medium, a significant (70%) decrease in the amplitude of cardiac contractions was observed.</p>
<p>However, the presence of the inhibitor did not prevent the occurrence of ventricular fibrillation. It appeared in 100% of experiments.</p>
<p>Based on the obtained experimental data, it was concluded that the leading role of Na-Ca exchange mechanism in the pathogenesis of cardiac ventricular fibrillation.</p>
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