Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10075Conference ProceedingsCytomegalovirus infection and herpes simplex virus types 1, 2 as a cause of the development of PVHDLoginovViktor Vadimovich<p>Student</p>V1ktorLog1nov@yandex.ruhttps://orcid.org/0009-0007-5605-0444KhokhlovaDaria Olegovna<p>Student</p>V1ktorLog1nov@yandex.ruhttps://orcid.org/0009-0004-3462-0731SavinykhMaksim Valerievich<p>Associate Professor of the Department of Infectious Diseases, Candidate of Medical Sciences</p>V1ktorLog1nov@yandex.ruhttps://orcid.org/0000-0003-4205-0463Kirov State Medical University2712202413278792604202416062024Copyright © 2024, Loginov V.V., Khokhlova D.O., Savinykh M.V.2024<p style="text-align: justify;">Introduction. Peripheral vitreochorioretinal dystrophy (PVHRD) is a pathological process on the periphery of the retina of the eye, which is the most common cause of its detachment. The exact cause of this pathology has not been fully established. There are several studies in which infectious factors also play a certain role in the pathogenesis of PVHRD. In a number of scientific papers, the development of dystrophies is associated with the persistence of cytomegalovirus infection (CMV) and infection caused by herpes simplex virus (HSV) types 1,2. The purpose of the work. To study the effect of CMV infection and/or herpetic infection caused by HSV types 1,2, confirmed by ELISA, on the development of retinal PVHRD. Materials and methods. We have studied the scientific literature on the effect of infectious agents on the development of retinal PVHRD. We conducted an analysis of outpatient charts and photos of PVHRD of patients of the KOGBUZ "KKOB" and the ophthalmological clinic "Constellation" in order to study the effect of infection caused by CMV or HSV 1, 2 on the formation of PVHRD of the retina. Statistical analysis was carried out using descriptive statistics methods in MS Excel and Statistica 10 programs. Results and conclusions. We presented the characteristics of retinal PVHRD against the background of the persistence of CMV infection and/or herpetic infection caused by HSV type 1, type 2. We found that 80.77% of the foci of dystrophy are located in the projection of retinal vessels, their manifestation is a local reaction to an infectious agent, which is local vasculitis. The majority of patients (91%) have a latticed type of degeneration, which may also indicate a viral etiology. PVHRD of other types, for example, dystrophy of the "snail track" type, are more often of a traction nature and are associated with retinal overgrowth due to an increase in the size of the eyeball against the background of myopia. It has been established that PVHRD can be observed in the presence of serological markers of both infections. Based on the data obtained, it is possible to trace the relationship between the presence of infectious markers indicating the long-term persistence of viruses and changes in the retina. Given the widespread prevalence of herpes viruses, the presence of IgG class antibodies to these pathogens is not convincing evidence of a link. The role of infectious factors in the development of PVHRD has not been fully studied, which indicates the need to continue research in this direction.</p>myopiaPVHRDcytomegalovirus infectionherpes simplex virusvasculitisмиопияПВХРДцитомегаловирусная инфекциявирус простого герпесаваскулит1.Балашова Л. А. Иммунологические факторы в патогенезе витреохориоретинальных дистрофий и дистрофической отслойки сетчатки, осложненной ПВР / Л. А. Балашова, В. Ю. Евграфов // Офтальмохирургия. – 1995. –№ 4. – С. 48-53.2.Бойко Э. В. Решетчатая дегенерация сетчатки / Э. В. Бойко, А. А. Суетов, Д. С. Мальцев // Вестник офтальмологии. – 2014. – Т. 2. – С. 77-82.3.Плотникова Ю. А. К вопросу о происхождении периферических витреоретинальных дистрофиях / Ю. А. Плотникова, Ю. В. Кудрявцева, А. Д. Чупров // Общенациональный офтальмологический форум: науч.-практ. конф. с междунар. участием, посвящ. 110-лет. юбилею МНИИ ГБ им. Гельмгольца. – Киров, 2010. – С. 210-215.4.Под редакцией В.А. Шаимовой. Периферические дистрофии сетчатки. Оптическая когерентная томография. Лазерная коагуляция сетчатки: атлас // — СПб, 2015. — С. 10-15.