FEATURES OF THE STRUCTURAL ORGANIZATION OF THE SKIN OF WOMEN IN THE OLDER AGE PERIOD WHO HAVE HAD THE DISEASE COVID-19

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Relevance. The SARSCoV-2 coronavirus pandemic, which began in December 2019, forced the world scientific and medical community to urgently develop approaches to the diagnosis, treatment and prevention of pneumonia associated with a new coronavirus infection (COVID-19). However, it soon became clear that the pathogenesis of the new coronavirus infection is extensive and affects many other body systems, as a result of which, in addition to developing treatment for the underlying disease, scientists had to face the need to revise the tactics of differential diagnosis and treatment of a number of other pathologies. Over time, more and more attention began to be paid to the study of dermatological manifestations, in particular due to concern for certain groups of patients, including those who were treated with immunosuppressants or immunomodulators. Of particular importance is the issue of studying the frequency of skin manifestations in COVID-19 in patients and patients with immunosuppression, since these categories of patients belong to a high-risk group both in terms of the incidence of COVID-19 and the severity of its course.The purpose of the study. To study the morphogenesis of changes in the structural components of the skin in female patients with Covid – 19 disease. Materials and methods of research. The study examined the features of morphofunctional changes in skin components in elderly and senile women (cadaveric material), whose underlying disease was not associated with skin pathology and patients who had undergone Covid-19. The patients were divided into two groups: control and experimental. Within the groups, patients were also divided into subgroups based on age: : I subgroup – patients whose age is less than 75 years (elderly age period), II subgroup – patients whose age is > 75 years (senile age period). The study material was skin fragments (2x2 cm). For the study, histological preparations were stained with hematoxylin and eosin, according to Mallory, according to Van Gieson, and studied in a light-optical direct microscope Eclipse 80i (Nikon, Japan). During the study of Altami Studio 3.0 and ImageJ 1.46h rograms.The results of the study. Among all patients, the thickness of the mesh layer is heterogeneous.So in the elderly subgroup of the main group (women < 75 years old)  higher than in the control group by 5.27%, but the same indicator in the senile subgroup of the main group (women > 75 years old)  lower than the control group by 4.74%.Among all patients, the thickness of the papillary layer in the main group is greater than in the control group. Within subgroups: in the senile subgroup of the main group (women > 75 years old)  this indicator is 40% higher, and in the elderly subgroup of the main group (women < 75 years old)  45% more than in similar subgroups of the control group.Among all patients, the ratio of the papillary layer to the mesh in the main group is greater than in the control group. Within subgroups: in the senile subgroup of the main group (women > 75 years old)  this indicator is 58.9% higher, and in the elderly subgroup of the main group (women < 75 years old)  67.14% more than in similar subgroups of the control group.Conclusions. Thus, in patients infected with SARS-CoV-2, the following inflammatory changes are observed in the skin: an increase in the number of lymphocytes, the thickness of the mesh layer and papillary layer due to interstitial edema. The most pronounced changes concern the papillary layer - there is a decrease in the ratio of the structural component to the amorphous substance. To a lesser extent, this indicator decreases in the mesh layer. In connection with the above, it can be assumed that such manifestations occur against the background of the action of the SARS-CoV-2 virus on the microcirculatory bed of the skin.

About the authors

Gabib Nazim ogly Sadygov

Email: gabibsadygov97@gmail.com
ORCID iD: 0000-0002-5267-0503
Russian Federation, 3, K. Markx str., Kursk, 305000, Russia

Ekaterina Sergeevna Mishina

Author for correspondence.
Email: katusha100390@list.ru
ORCID iD: 0000-0003-3835-0594
SPIN-code: 5694-2294
Russian Federation, 3, K. Markx str., Kursk, 305000, Russia

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