EVALUATION OF THE EFFECTIVENESS OF TREATMENT WITH APIXABAN IN COMORBID PATIENTS IN THE BURN DEPARTMENT OF A MULTIDISCIPLINARY HOSPITAL
- Authors: Kadyseva E.1,2
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Affiliations:
- Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
- Kazan State Medical Academy
- Issue: Vol 11 (2022): Materials of the XVIII International Burdenkov Scientific Conference on April 14-16, 2022
- Pages: 229-229
- Section: Клиническая фармакология и фармакоэкономика
- URL: https://new.vestnik-surgery.com/index.php/2415-7805/article/view/7457
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Abstract
The thesis presents a retrospective analysis of the case histories of 105 comorbid patients in the burn department in order to identify complications during treatment with apixaban.
Keywords
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Relevance. One of the complications that poses a serious threat to the life of patients with burn injuries is a violation of the rheological properties of the blood. Especially this situation becomes more noticeable in comorbid patients who have a history of disorders of the cardiovascular system.
Target. To analyze patients of the burn department who received apixaban therapy.
Material and methods. A retrospective analysis of case histories of 105 patients (53 men and 52 women) of the burn department with concomitant diseases.
Results. The average age of patients in the burn department was 54.6±18.004. All patients received apixaban therapy (100%). Patients with burns up to 5% amounted to 42.4%, up to 10% -21.1%, up to 20% -18.3% and up to 30% or more - 18.2%. Among the most common comorbid conditions were: hypertension - 59.9%, coronary heart disease - 34.6%, chronic heart failure - 22.1%. The average duration of hospital treatment was 26.834 ± 3.804 days (p=0.00007).
Conclusions. It was noted that in patients with two or more chronic comorbidities, and even with a larger area and depth of burns during treatment with apixaban, there were no complications in the form of venous thromboembolic complications (VTEC), stroke, deep vein thrombosis (DVT) and pulmonary embolism ( TELA). In addition, the results of the coagulogram and the index of the clinical analysis of blood - platelets remained normal.
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About the authors
Elvina Kadyseva
Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan; Kazan State Medical Academy
Author for correspondence.
Email: Elvina_Ganeeva@mail.ru
ORCID iD: 0000-0002-4453-1175
Clinical pharmacologist, first category, researcher of the Department of Clinical Pharmacology
Russian Federation, 420138, Russia, Kazan, Orenburg tract 138
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