REACTIVE CHANGES OF CONNECTIVE TISSUE TO HERNIOPLASTY IMPLANTS


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Abstract

The change in the ratio of type I and type III collagens, as a manifestation of connective tissue dysplasia, has attracted the attention of surgeons in recent years. In this connection, hernioimplants with collagen-stimulating coating are of great interest to surgeons.

Full Text

Relevance: The change in the ratio of collagens of types I and III, as a manifestation of connective tissue dysplasia, has attracted the attention of surgeons in recent years [1, 2]. In this connection, hernioimplants with collagen-stimulating coating are of great interest to surgeons [3].The aim of the study was to compare morphological changes in the tissues of the anterior abdominal wall of animals at the site of endoprosthesis.Material and methods: the experimental part of the study was performed on 45 rats who underwent endoprosthetics with a supra-aponeurotic prosthesis arrangement. In group 1, a polypropylene mesh hernioimplant was used. In group 2, a polypropylene hernioimplant coated with dexpanthenol was used. In group 3, a polypropylene hernioimplant coated with ascorbic acid was used. The animals were removed from the experiment on the 7th, 30th, 90th day. Results: as a result of the study of experimental samples in all three groups, around the threads of hernia implants, at the late stages of the experiment, the formation of a connective tissue capsule was noted, in which mature collagen fibers were present. In group 3, the most optimal morphological picture of implant engraftment was revealed. Such changes could occur due to the stimulation of collagenogenesis by the coating used in the experiment. Conclusions: The observed morphological signs in the tissue surrounding the hernioimplant indicated an optimal reaction in the group with ascorbic acid coating. It was also revealed that this material had the best biological inertia, integrated well into the surrounding tissue, and the coating reduced the reaction of body tissues to the implant.

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About the authors

Irina Ponomareva

Kursk State Medical University

Author for correspondence.
Email: ira.ponomareva92@mail.ru
ORCID iD: 0000-0003-1850-6491

Assistant of the Department of Surgical Diseases № 1 Kursk State Medical University

Russian Federation, Karl Marx str., 3, Kursk

Andrey Viktorovich Tsukanov

Kursk State Medical University

Email: tsandrej@yandex.ru
ORCID iD: 0000-0001-7578-6835

Associate Professor of the Department of Surgical Diseases №1

Russian Federation, Karl Marx str., 3, Kursk

Maria Alekseevna Zatolokina

Kursk State Medical University

Email: marika1212@mail.ru

Professor, Department of Histology, Embryology, Cytology Kursk State Medical University

Russian Federation, Karl Marx str., 3, Kursk

Ilya Sergeevich Ivanov

Kursk State Medical University

Email: ivanov.is@mail.ru

Professor of the Department of Surgical Diseases № 1 Kursk State Medical University

Russian Federation, Karl Marx str., 3, Kursk

Sergey Viktorovich Ivanov

Kursk State Medical University

Email: ivanovsv@kursksmu.net
ORCID iD: 0000-0001-7540-5748

Professor of the Department of Surgical Diseases № 1Kursk State Medical University

Russian Federation, Karl Marx str., 3, Kursk

References

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  2. Иванов С.В., Иванов И.С., Цуканов А.В., Гафаров Г.Н., Объедков Е.Г. Влияние витамина с на динамику соотношения коллагена I и III типов в области имплантации герниопротеза у мышей. //Цитология. -2016. -Т. 58. -№ 9. С. 714-719.
  3. Кириенко А.И., Никишков А.С., Селиверстов Е.И., Андрияшкин А.В. Эпидемиология грыж передней брюшной стенки // Эндоскопическая хирургия. - 2016. - №4. - С. 55-60.

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