• Authors: Panarina N.1
  • Affiliations:
    1. Курский государственный медицинский университет
  • Pages: 33-35
  • Section: Результаты фундаментальных и прикладных исследований
  • URL:

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Purpose: to study the frequency and structural features of side effects of glucocorticosteroid drugs. Materials and methods: 58 patients of the rheumatology department who received glucocorticosteroid therapy for a long time were examined. Results. The frequency of side effects of hormone therapy with glucocorticoids was revealed. The structural features of side effects were also analyzed and it was found that arterial hypertension is the most common. The least common is osteoporosis.



Full Text

Relevance. Glucocorticoids are hormones produced in the zona fasciculata of the adrenal cortex. Glucocorticoid preparations are used to treat many diseases, such as rheumatism, bronchial asthma, allergic reactions, dermatological pathologies, autoimmune processes, etc. Also, drugs of this group are indispensable in the treatment of shock conditions. However, in addition to many useful properties, glucocorticoids often cause side effects. Among them: steroid diabetes, increased blood pressure, osteoporosis, instability to infectious diseases, stomach ulcers, mental disorders (depressive states), the appearance of edema [1, 2].

Purpose of the study: pleasure from the manifestation of side effects of glucocorticosteroid drugs. The study was conducted with the following objectives: to identify functions, to identify and contraindicate glucocorticosteroid drugs, to analyze the prevalence of manifestations of certain side effects.

Research materials. The study involved 58 patients of the rheumatology department of the Kursk Regional Clinical Hospital receiving therapy with glucocorticosteroid drugs. Patients were asked to answer a series of questions, revealing that they had side effects when taking glucocorticosteroids.

Results and its discussion. Of the 58 respondents who received glucocorticosteroid therapy for a long time (at least 1 year), 27% noted that no side effects were observed while taking the drugs. 2% observed phenomena of osteoporosis in themselves, such as: cracks in long tubular bones, fractures that became more frequent during therapy. 37% of respondents noted an increase in blood pressure, 12% experienced an increase in blood glucose levels, mental disorders (depressive states) were observed by 4% of respondents. 7% of respondents complained about the appearance of edema during therapy. During therapy, 7% of respondents developed dyspeptic symptoms, 4% were diagnosed with gastric ulcer and erosive gastritis.


  1. As a result of the study, it was found that side effects from long-term use (more than 1 year) of glucocorticosteroids occur in 73% of cases, which indicates the need for patients to monitor their condition during therapy and the possibility of obtaining a timely consultation from the attending physician to adjust prescriptions.
  2. The most common side effect among respondents (37%) is an increase in blood pressure, which complicates therapy for patients suffering from arterial hypertension.
  3. The least common side effect (phenomena of osteoporosis: fissures and fractures of long tubular bones) was present only in 2% of the respondents, which may be due to the lower reactivity of the skeletal system compared to the rest.

About the authors

Natalia Panarina

Курский государственный медицинский университет

Author for correspondence.


Russian Federation


  1. Кушакова, К.А. Глюкокортикостероидные препараты / К.А. Кушакова, А.В. Конакова // Инновации. Наука. Образование. – 2021. – №46. – С. 2188-2193.
  2. Игнатенко, О.В. Глюкокортикоидные гормоны в практике терапевта / О.В. Игнатенко, В.П. Водоевич // Журнал Гроденского государственного медицинского университета. – 2006. – №1. – С. 7-13.

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