Cirrhosis of the liver as an outcome of chronic hepatitis C

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The adoption currency A virus that parasitizes the liver, which can be transmitted through the blood, from mother to child, sexually, leads to the development of cancer (hepatocellular carcinoma) and sometimes to the death of the patient. HCV is required to prescribe antiviral therapy and diet, but the appointment of interferons with combinations of antiviral agents does not allow achieving the desired effect in treatment, especially in a number of patients who received interferons, there are many undesirable side reactions. At the moment, the diagnosis of viral hepatitis is very problematic, since viral hepatitis is latent. The patient usually does not feel pain in the right hypochondrium, the absence of jaundice, which will be associated with liver disease. PURPOSE How does chronic hepatitis C affect the development of liver cirrhosis? METHODS Study design The study included 60 patients all over the age of 18, of which 30 were patients with cirrhosis of the liver and chronic hepatitis C, and about 30 were patients with cirrhosis of the liver without chronic hepatitis C. The remaining 30 patients with CP and without CHC, these patients did not receive antiviral therapy and the approximate duration of CHC disease was 15 years. The median age was 48 years. A BMI of 25kg/m. In these patients, 10 people (32%) had a viral load of (<300,000 IU/ml), and 20 people (68%) had a viral load of more than (>600,000 IU / ml) there were an equal number of them, both among men and women with cirrhosis of the liver without chronic viral hepatitis C. The average age of patients was 64 years, BMI 30 kg / m2. the degree of expansion of esophageal varicose veins is second degree, reflux esophagitis is erosive in 20 patients (68%). All patients were found to have thrombocytopenia up to 100 thousand, hypoalbuminemia, and a decrease in the protombirovannoo index to 70. All patients in the control group had a degree of liver fibrosis F 3 by indirect liver elastometry. Functional class of cirrhosis of the liver according to child-Pugh class A - in 6 people, class B-in 10 people, class C-in 4 people.Compliance criteria The study did not include patients with HCG, patients with HIV, type 2 diabetes. In the inclusion criteria were: men and women aged 18 years and older tested positive for the presence of antibodies to the hepatitis C positive test for the presence of RNA for hepatitis C in serum, the presence of signs of portal hypertension by ultrasound OBP extension of the splenic vein and portal vein, the presence of signs of portal hypertension according to FGDS dilatation of the esophagus and stomach, signs of liver cirrhosis defined according to the indirect alstromeria liver.Resultsin a study of the CP +CHC group, it was found that middle-aged patients are ill, both among women and men, all patients (100%) were found to have esophageal lesions and F4 degree by indirect liver elastometry, as well as a viral load(more than >600000ml/IU), and a functional class according to child Pugh class A-7, class B-5,class C-12 patients.conclusion, when developing individual treatment tactics for HCV, it is necessary to take into account the type of virus, active alcohol consumption, tobacco Smoking.

About the authors

Mariya Alekseevna Parfenteva

Tyumen State Medical University

Author for correspondence.
Email: mp_97@mail.ru
ORCID iD: 0000-0002-7871-3452
SPIN-code: 6190-7190

Student

Russian Federation, г Тюмень, ул. Одесская 54

Dmitrii Rubcov

Тюменский Государственный Медицинский Университет

Email: Rudibossy@mail.ru
ORCID iD: 0000-0002-2090-7115
SPIN-code: 3681-9706
Russian Federation, г Тюмень, ул. Одесская 54

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