Vol 22, No 3 (2019)

Articles
STRUCTURE OF EXOGENOUS POISONING IN CHILDREN TAKING INTO ACCOUNT THEIR AGE (LITERATURE REVIEW)
Karpushkina E.S., Zhdanova O.A., Batischeva G.A., Lyubavskaya S.S., Petukhova Y.A.
Abstract
Acute poisoning is of key importance in medical pathology of children. The environment is constantly accumulating new xenobiotics, and there is no information about their detoxification in poisoning. The article presents a literature review on frequency of occurrence and the structure of exogenous poisoning in children in Russia and other countries. Most often poisoning was recorded in children aged under 4-6 years (from 41.6% to 76.8% in different countries). Drug poisoning prevailed among the total cases (49.6 - 68.0%), poisoning by household chemicals (29.8 - 36.0%), alcohol (14.0%) and narcotic substances (22.6%) were also quite often. There was a large number of accidental poisoning (up to 90%) due to improper storage of medicines at home accessible to children. Conscious administration of toxic substances for suicidal purpose was registered in adolescents. Study of the structure of exogenous poisoning will allow to take targeted preventive measures.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):4-9
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ANALYSIS OF PHARMACOTHERAPY OF DISEASES OF THE UPPER DIGESTIVE TRACT IN CHILDREN IN A CLINICAL SETTING
Zhdanova O.A., Nedoluzhko Y.S., Dronova Y.M.
Abstract
A clinical and pharmacological evaluation of rationality of the treatment of diseases of the upper digestive tract in children in accordance with the clinical recommendations was carried out. A retrospective analysis of 50 case histories of children aged 4 to 17 years old treated in a specialized gastroenterological department in 2015-2017 was performed. In 78% of the patients chronic gastroduodenitis was associated with gastroesophageal reflux disease and reflux esophagitis, in 54% of the children - with billiard tract lesion, in 26% of the patients - with intestinal diseases and in 14% of the children - with reactive pancreatitis. Antisecretory therapy was conducted only in 78% of the patients, whereas eradication therapy with two antibacterial medicines was performed in 48% of the cases of confirmed H. pylori infection and majority of the patients (67%) received antibiotics in smaller doses than recommended. Only 13% of the patients with gastroesophageal reflux disease were treated with prokinetics and motility correctors. Conducting therapy in accordance with the clinical guidelines and medicines instructions will contribute to an effective and safe treatment of patients.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):10-15
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PHARMACOTHERAPY OF ENTEROVIRAL MENINGITIS IN CHILDREN
Nazarieva N.A., Begina O.A., Gladchuk N.V., Kokoreva S.P., Kotlova V.B., Pokataeva A.K., Zhdanova O.A.
Abstract
A retrospective analysis of case histories of 63 children aged 1 to 17 years with serous meningitis of enterovirus etiology, who were treated in a specialized department during the autumn-winter period of 2013-2016, was carried out.Effectiveness of the treatment was assessed according to the dynamics of regression of clinical symptoms during the acute period of the disease,presence or absence of side effects of pharmacotherapy; a pharmacoeconomic analysis of the treatment cost per patient was carried out.Allpatientsreceivedantiviral, antibacterialanddehydratingtherapy, nootropics.Noadversesideeffectsofthetherapywereobserved.A more rational approach to prescribing drugs and compliance with the standard of the treatment were noted in 2013 which correlated with the minimum treatment cost.In 2016 and 2017the pharmacotherapy conducted was recognized as rational in 70% of the cases.A treatment algorithm for enterovirus meningitis is developedbased on the clinical and pharmacological analysis which makes possible to increase effectiveness of the therapy and reduce the treatment cost.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):16-21
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PHARMACOTHERAPY OF HYPERTENSION IN ADOLESCENTS WITH OVERWEIGHT AND OBESITY
Gusareva A.A., Batischeva G.A., Zhdanova O.A., Chubarov T.V., Pakhomova Y.A., Platonov D.O.
Abstract
Изучены особенности клинического течения и эффективности фармакотерапии у 72 подростков с синдромом артериальной гипертензии. Антигипертензивную терапию не получали 39 детей (1 группа), получали - 33 подростка (2 группа). Во 2 группе преобладали дети с ожирением и избытком массы тела (72,7%). Стабильное течение артериальной гипертензии наблюдалось у 32,4% детей в первой группе и у 68,8% подростков во второй группе (p<0,05). В 1 группе использовались ноотропы, вазоактивные, метаболические препараты; во второй - ингибиторы АПФ, бета-блокаторы, диуретики и препараты центрального действия (моксонидин). В 1 группе не достигли стабилизации артериального давления 5,1% детей, во второй - 18,2%, все пациенты имели избыток массы тела и ожирение. Течение артериальной гипертензии у детей с избытком массы тела и ожирением прогностически более неблагоприятное, чем у подростков с нормальной массой тела, характеризуется более высокими показателями артериального давления и резистентностью к антигипертензивной терапии.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):22-27
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USE OF ANTIBACTERIAL REMEDIES IN CONJUNCTIVITISOF CHILDREN IN OUT PATIENT DEPARTMENT CONDITIONS
Uskenbayev T.B., Tilekeeva U.M.
Abstract
The article discusses the issues of local application of drugs in the form of eye drops and ointment in the treatment of conjunctivitis in pediatric practice in an outpatient setting. Of the antibacterial agents, the most frequently used was tobromycin, followed by ofloxacin and levofloxacin, followed by chloramphenicol and sulfa drugs. In viral conjunctivitis, the main treatment consisted in the local combination of eye drops of oftalmoferon, poludan and eye acyclovir ointment. Allergic conjunctivitis was treated with lecrolin eye drops and combined prepates with glucocorticoids. The average duration of treatment of bacterial conjunctivitis was 7 days, with viral conjunctivitis 11 days, and with allergic conjunctivitis, the average duration of treatment was 14 days. It was revealed that the duration of treatment is influenced by the timing of treatment to a specialist. An important role in the lengthening of the terms of treatment of conjunctivitis was played by the fact of self-treatment, which every tenth patient had.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):28-32
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PRIMENENIE VYSOKOOChIShchENNYKh IMMUNOGLOBULINOV DLYa VNUTRIVENNOGO VVEDENIYa V DETSKOY ONKOGEMATOLOGII
Grebennikova I.V., Yudina N.B., Zhdanova O.A., Belyanskaya M.V., Solovyova M.A., Trubnikova G.V., Skorobogatova D.A., Orlova E.A., Ovchinnikova Y.S.
Abstract
Одним из современных препаратов крови, все более широко применяемым в педиатрии, является иммуноглобулин человека нормальный для внутривенного введения. В статье отражен практический опыт использования внутривенных иммуноглобулинов (ВВИГ) в детской онкогематологии. Данные препараты применяли для лечения аутоиммунных заболеваний (иммунная тромбоцитопения, аутоиммунная гемолитическая анемия), заместительной терапии первичных и вторичных иммунодефицитных состояний, профилактики инфекционных осложнений и лечения сепсиса. Показано, что использование ВВИГ в детской практике безопасно и эффективно. Однако, необходимо дальнейшее совершенствование технологии производства и очистки ВВИГ с целью минимизации побочных реакций, а так же разработка и внедрение новых фармацевтических форм (подкожные и пэгилированные формы).
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):33-39
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ANALYSIS OF THE MEDICINE RESOURCE IN STENOCARDIA THERAPY ON THE REGIONAL PHARMACEUTICAL MARKET
Terskikh A.P., Rudakova L.V., Gridneva L.G., Kryuchkova A.V.
Abstract
Приведены результаты комплексного маркетингового анализа лекарственного ресурса для терапии одного из наиболее часто встречающихся заболеваний сердечно-сосудистой системы - стенокардии. Сделан обзор причин, вызывающихстенокардию. В последнее время на фармацевтическом рынке нашего государства наблюдается постоянное расширение товарной номенклатуры за счет регистрации большого количества воспроизведенных лекарственных препаратов и биологически активных добавок для лечения и профилактики любого класса заболеваний, что требует периодического пересмотра и коррекции проводимой фармакотерапии. Основываясь на изучении используемых в настоящее время рекомендаций и стандартов лечения, обобщен и сгруппирован информационный массив лекарственных средств для терапии заболеваний, относящихся по международной классификации болезней к шифру I20. Приведены структуры ассортимента лекарственных препаратов в зависимости от фармакологических групп, действующих веществ, торговых наименований, а также производителей. Описаны биохимические основы действия некоторых фармакологических групп лекарственных препаратов в терапии стенокардии. Составлен макроконтур ассортимента целевого сегмента фармацевтического рынка для терапии стенокардии.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):40-47
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ADVERSE REACTIONS TO ANTITUBERCULOSISDRUG
Perova N.N., Batischeva G.A., Muzalevskaya E.N., Atyakshin D.A.
Abstract
Работа посвящена анализу рисков возникновения побочных реакций противотуберкулезной химеотерапии. Проведен ретроспективный анализ извещений о нежелательных побочных реакциях на противотуберкулезные препараты, зарегистрированных в Воронежской области в 2016-2018 гг. Исследованы наиболее часто встречающиеся осложнения противотуберкулезной терапии. Изучены взаимосвязи применения различных препаратов с возникающими нежелательными реакциями, дана оценка частоты их возникновения. В структуре нежелательных реакций преобладали гепатотоксические реакции - 70%, которые чаще всего регистрировались при режиме химиотерапии I, интенсивная фаза (препараты Изониазид, Рифампицин, Пиразинамид, Этамбутол). Основными факторами возникновения нежелательных реакций являются длительность противотуберкулезной терапии и использование одновременно нескольких препаратов, обладающих однонаправленными побочными эффектами.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):48-53
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ANALYSIS OF THE RATIONALITY OF PURPOSE OF MEDICINES OF NON-SPECIFIC PHARMACOTHERAPY BY PATIENTS WITH TUBERCULOSIS IN A HOSPITAL BASED ON DATA OF EVIDUAL MEDICINE
Arapbaeva D.A., Tilekeeva U.M.
Abstract
The article analyzes the rationality of the use of drugs pathogenetic and symptomatic therapy in patients with newly diagnosed pulmonary tuberculosis, on the basis of evidence-based medicine. Revealed non-compliance with WHO indicators for proper prescription of drugs, a high level of polypharmacy of drugs of non-specific pharmacotherapy, against the background of etiotropic treatment with 4-5 antituberculosis drugs. The findings indicate low adherence to the clinical guidelines for organizing tuberculosis control in the Kyrgyz Republic and WHO recommendations for the prevention and treatment of isoniazid-induced hepatitis, the dosage regimen and the route of administration for pyridoxine hydrochloride. In actual clinical practice, a significant portion of tuberculosis patients receive non-targeted therapeutic drugs with unproven efficacy, which have no indication for use for this category of patients.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):54-59
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FARMACOLOGICAL CORRECTION OF POSTOPERTIVE HYPOXIA OF BRAIN AT CARDIOSURGICAL PATIENTS
Batischeva G.A., Goncharova N.Y., Kuznetsov D.S., Ivachnenko D.V.
Abstract
Исследованы последствия влияния кардиохирургических вмешательств в условиях искусственного кровообращения у 35 пациентов. Программа обследования включала методы психологического тестирования - методика HADS, опросник «типа отношения к болезни», опросник DS-14, а также MoCA-тест для оценки состояния когнитивных функций. У всех пациентов после аортокоронарного шунтирования проведен мониторинг фармакотерапии в послеоперационном периоде. Установлено, что когнитивные нарушения имели 70% пациентов, нарушения сна отмечены у 29% исследуемых, наличие одновременно тревожных расстройств и депрессии было у 23% пациентов. В клинической практике установлена низкая частота назначения препарат Мексидол для коррекции когнитивных нарушений - только у 15% пациентов, что указывает на недостаточную терапию постгипоксических нарушений у пациентов после кардиохирургических вмешательств.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):60-64
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DETERMINING THE CONCENTRATION OF METHEMOGLOBIN IN PATIENTS WITH CARDIOVASCULAR DISEASE AND COPD ON THE BACKGROUND OF DRUG THERAPY
Boev K.V., Vasilenko D.V., Budniewski A.V., Safonov A.A., Gamtenadze G.B.
Abstract
The levels of methemoglobin concentration (MetHb) in patients with cardiovascular disease and COPD were studied. In patients with cardiological profile, the concentration of total cholesterol was additionally determined, in patients with COPD the concentration of carboxyhemoglobin (COHb) was determined. Studies have shown that MetHb concentrations were higher in patients with cardiovascular disease. Methemoglobinemia was accompanied by elevated cholesterol levels. In COPD patients, the level of MetHb was within the physiological norm against the background of increased concentration of COHb. Comparative analysis of drug formulas showed that patients with cardiological profile take more toxic drugs. Since the catabolism of xenobiotics is accompanied by the generation of NO, it can be assumed that hemoglobin is oxidized more intensively in patients with cardiovascular disease.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):65-68
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OPTIMIZATION OF ANTIPLATELET THERAPY IN PATIENTS WITH CORONARY ARTERY REVASCULARIZATION ON THE BASIS OF PHARMACOEPIDEMIOLOGICAL ANALYSIS
B. A. Yeraliyeva I.A., Zhaipanov M.T., Erkinbekova G.B., Kiekova B.H., Nakisbekova K.K.
Abstract
Currently resistance to clopidogrel therapy is a serious problem. One of the most commonly used antiplatelet agents in the world is the clopidogrel P2Y12 receptor blocker.The lack of response to therapy, or resistance, occurs in 5 to 45% of cases and may be due to gender, age, diet, non-compliance with the prescribed treatment regimen, possible drug interactions, including the cytochrome P450 system, taking non-steroidal anti-inflammatory drugs, proton pump inhibitors, obesity, diabetes, insulin resistance, Smoking, C-reactive protein levels and genetic polymorphism.. In this paper we studied the pharmacoepidemiological analysis in the cardiology Department of the regional hospital in order to select an individual dose of antiplatelet therapy in Kazakhs with revascularization of the coronary artery.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):69-72
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EFFECT OF UV LIGHT AND DEXAMETHASON ON THE PRODUCTION OF IL-2 AND ITS RECEPTOR BY BLOOD LYMPHOCYTES OF DONOR AND PATIENTS WITH BRONCHIAL ASTHMA
Zemchenkova O.V., Savostina I.E., Basharina O.V.
Abstract
Исследованы способность лимфоцитов продуцировать ИЛ-2 и экспрессировать CD25 маркеры на лимфоцитарных мембранах в условиях воздействия на суспензию клеток крови доноров и больных бронхиальной астмой УФ-света (240-390 нм) в дозе 151 Дж/м2 и дексаметазона. Показано, что синтез интерлейкина Т-клетками значительно возрастает после их фотомодификации, при добавлении дексаметазона к фотомодифицированным лимфоцитам концентрация цитокина снижается до уровня интактных клеток. УФ-свет приводит к повышению как количества CD25+-клеток, так и уровня экспрессии CD25-рецептора. Концентрация ИЛ-2 у больных астмой несколько ниже нормальных показателей, в результате курса фототерапии у больных изначально пониженный уровень ИЛ-2 достигает уровня, сопоставимого с зарегистрированным у здоровых доноров.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):73-78
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L-ARGHININ IN THE COMPOUND OF STANDARD PHARMACOTHERAPY ARTERIAL HYPERTENSION WITH ADAPTATION DISORDER: SAFETY OF LONG-TERM APPLICATION
Nalotova O.S.
Abstract
The article presents the results of a study on the safety assessment of L-arginine at a dose of 750 mg per day (two-week courses) as part of standard antihypertensive pharmacotherapy in patients with arterial hypertension stage II and with adaptation disorder for 24 weeks. The safety of treatment was monitored by determining the effect of treatment on the following blood parameters: the number of erythrocytes, leukocytes, hemoglobin content, erythrocyte sedimentation rate, creatinine, total bilirubin, alkaline phosphatase, alanine aminotransferase, aspartaminotransferase and electrolytes (sodium, potassium, calcium, chlorine). The results indicate that the inclusion of L-arginine in the standard therapy does not adversely affect the blood formation processes, as well as the basic metabolic processes in the body.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):79-84
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INVESTIGATION OF POSSIBILITIES OF USING THE BROMTHYMOL BLUE NDICATOR AS EXPRESS DIAGNOSTICUM FOR OPTIMIZATION OF PHARMACOTHERAPY IN WOMEN WITH IMPAIRED VAGINAL BIOCOENOSIS
Khoroshikh N.V., Madykin Y.Y., Mittova V.O., Soloveva A.A.
Abstract
The task of correcting violations of the vaginal microbiota is quite difficult to solve. Despite the diversity of modern diagnostic capabilities, identification of the causative agent of vaginal disease is rather difficult, therefore the treatment is often prescribed symptomatically. The article is devoted to the possibility of using the indicator of bromthymol blue for the early diagnosis of disorders of the vaginal biocenosis in order to optimize the selection of pharmacotherapy. Various methods for preparing solution indicators are discussed and a method for preparing a solution for application to a sanitary pad for dynamic control of the pH of vaginal secretions is proposed. Bromthymol blue is a generally suitable indicator for dynamic control of changes in the pH of vaginal secretions, since the indicator is highly sensitive to pH> 6 and sufficiently sensitive in the pH range from 4 to 5. The feasibility of using a solution of bromthymol blue in glycerol as an express diagnosticum has been determined.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):85-89
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USE OF METHOD OF EMPIRICAL SELECTION OF PHARMACOTHERAPY IN CASE OF VAGINAL BIOCENOSIS DISORDERS WITH THE HELP OF PH-MEASUREMENT OF EXCRETIONS
Khoroshikh N.V., Madykin Y.Y., Mittova V.O., Soloveva A.A.
Abstract
Несмотря на значительное количество методов для диагностики степени нарушения влагалищной микробиоты и подбора оптимальной фармакотерапии, применение этих методов достаточно ограниченно. Ограниченность использования обусловлена проблематичностью использования в массовом масштабе методов диагностики, не включенных в стандарты ОМС, а также тем фактом, что для многих групп пациенток достаточно применения скрининговых методик. Базовой скрининговой методикой является pH-метрия. Эффективность данного метода определяется использованием индикатора, реагирующего на изменение рН в необходимомдиапазоне. Статья посвящена возможности использования индикатора метилового красного для оптимизации подбора фармакотерапии у женщин с нарушением биоценоза влагалища. Предложены методика приготовления раствора индикатора для использования в качестве экспресс-диагностикума.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):90-94
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POSSIBILITY OF USING OF PETAL DIAGRAMS FOR QUANTITATIVE ESTIMATION OF PYRIDOSTYGMINE BROMIDE IN THEDOSAGE FORM
Alekhina M.I., Nikitina T.N.
Abstract
The article consist information about the possibility of using petal diagrams that was constructed from the results of spectrophotometric studies to doqualitative and quantitative determinationof pyridostigmine bromide in the Kalimine 60 N. Pyridostigmine bromide - the main ingredient of the anticholinesterase drug Kalimin 60 N - is used in the treatment of myasthenia gravis, myasthenic syndrome and other diseases associated with impaired neuromuscular conduction. The method of UV-spectrophotometry is one of the express and informative methods of pharmacopeia’s analysis, which currently use in analytical laboratories. It was shown that the petal diagrams make a more vivid two-dimensional representation of the spectra of solutions of the substance and the dosage form, and allow us to estimate the rate of change of the amount of the active substance during storage of the dosage form. It was shown that the obtained profiles of the substance and the drug completely match only if the drug consist right amount of original and good quality active substance.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):95-99
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CREATION OF PROLONGED AND LOW-TOXIC FORMS OF ANTI-BACTERIAL MEANS BASED ON BIOPOLYMERS
Makarova E.L.
Abstract
This article discusses the problem of creating immobilized drugs in order to reduce the toxic effect, as well as the emergence of the possibility of a selective effect of the obtained drug. The materials of the study used a commercial preparation of ampicillin trihydrate of the company "Biosynthesis", which was adsorbed on collagen isolated from the dermis of pond fish. The concentration of ampicillin in the immobilized preparation was calculated using the method with the use of the phenol reagent Folin-Chocalteau, and the activity - by the diffusion method in agar. The formation of the antibiotic-collagen complex provides a prolonged effect of the obtained preparation. Sufficiently high concentrations of the antibacterial drug in the wound tissues can be maintained directly in the wound tissues for many days with a single injection into the wound. The conducted studies lead to the conclusion that collagen isolated from the dermis of pond fish can be used as a carrier for creating prolonged and weakly toxic forms of antibacterial agents.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):100-103
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OPPORTUNITIES OF DIGITAL COLORYMETRY IN PHARMACEUTICAL ANALYSIS
Rudakova L.V., Vetrova E.N., Nikitina T.N., Alekhina M.I.
Abstract
The article is devoted to the application of digital colorimetric analysis to control the quality and authenticity of pharmaceutical products. It is proposed to use a colorimetric approach to identify and quantify medicinal substances with their own color or fluorescence, as well as their colored derivatives. The advantage of the digital colorimetric approach is that it is possible to use any kind of household digital devices for recording an analytical signal (photo or web camera, scanner with a slide adapter and smartphone). The next advantage of this method is the ability to analyze the obtained images using standard computer programs for image processing (we used the program Adobe Photoshop). It was shown that the dependence of the intensity of the chromaticity of the samples on the concentration of the drug in the solution can be used as calibration for carrying out quantitative determinations. The proposed method allows determination in a wide range of concentrations. This method is economical, affordable, express, does not require a special tool base, assuming the use of conventional digital devices and standard software packages.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):104-109
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CHANGES IN THE BIOCHEMICAL INDICATORS OF RAT BLOOD DURING A LONG-TERM EXTREME CONSUMPTION OF PALM OIL, SODIUM GLUTAMATE AND SUGAR INFLUENCE OF DERIVATIVES SALICYLENE ISONICOTINOILHYDRAZONES
Bibik E.Y., Kutenets A.S., Abramenko V.L., Tilchenko D.A., Myazina A.V.
Abstract
Recently, there has been an increase in the production and use in the food industry, starting with baby food, various types of vegetable oils, monosodium glutamate and sugar, but the question of their influence on a living organism during long-term use remains unexplored. The experiment studied the effect of excessive long-term use of common food additives and palm oil on the body's metabolic processes and the pharmacocorrection of identified violations of the salicylidene isone-isonisotinoylhydrazone derivatives (isonicotinoyl-hydrazone 5-nitrosalicylic aldehyde and 3-methoxysalicyldidene-azotinoyl azidylohydrozone). The article presents the results of changes in the biochemical parameters of rats' blood after prolonged excessive consumption of palm oil (40 g / kg), monosodium glutamate (300 mg / kg) and sugar (2.5 g / kg) and their correction by salicylidenisonicotinoyl hydrazone derivatives. During the experiment, hepatoprotective properties were revealed in the spectrum of their pharmacological activity.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):110-115
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FEATURES OF ANTICOAGULANT THERAPY WITH WARFARIN IN REAL CLINICAL PRACTICE
Ukolova E.A., Somova M.N., Batischeva G.A.
Abstract
The purpose of this work was to identify the features of the use of warfarin by patients in real clinical practice in outpatient and inpatient settings on the basis of a non-Governmental health care institution "Road clinical hospital at the station Voronezh-1 JSC "Russian Railways". The questions concerning the need for pharmacogenetic testing to personalize the dosage of warfarin study group of patients, as, despite the careful selection of doses of warfarin, a rational combination of it with other drugs, patients compliance with the necessary diets and prescriptions of doctors, almost every second patient has not reached the target level of international normalized ratio (INR).
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):116-120
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INFLUENCE OF COMPOSITION OF EXTRACELLURAR MEDIUM ON EFFECTIVITY OF “NEOTON” AT CALCIUM PARADOX
Alabovsky V.V., Vinokurov A.A., Khamburov V.V., Maslov O.V.
Abstract
Phosphocreatine is not only energy buffer, but energy shuttle in some kind of cells. Because of it, is based use of phosphocreatine at energy- deficient pathological states. However, use of phosphocreatine at states related with Ca2+ overload exacerbates cellular damage. Criteria of cell injury were: coupling of respiration and phosphorylation in mitochondria, rate of ADP phosphorylation by isolated mitochondria, release of myoglobin from heart, tissue level of ATP, ADP, AMP, phosphocreatine and creatine. It has been established that only maintenance of high transmembrane Na+ gradient on sarcolemma causes highly specific unique positive protective effect of phosphocreatine. Combination of phosphocreatine with elevated transmembrane gradient has been blocked with strophantine, an inhibitor of Na+, K+ -ATPase. Action of elevated concentration of Na+ has not been related with increased osmotic pressure of the solution.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):121-126
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ROJECT "QUICK SOLUTION": RESEARCH OF EFFICIENCY OF DRUGS OF PLASMA OF THE DAPPLED DEER AT ASEPTIC DAMAGES OF THE CORNEA
Kovalevskaya M.A., Donkareva O.V., Berezhnova T.A., Sergeeva M.I., Preobrazhenskaya N.S.
Abstract
In article the problem of the correct empirical diagnostics and specific treatment of aseptic damages of a cornea rises. The diseases having similar symptom complex demand purpose of various active ingredients. The diseases that have similar symptomocomplex, require the appointment of various active substances. Research aimed at studying of increasing issues the efficiency of emergency care and methods patients with cornea pathology treatment with the help of applications of drugs based on blood of deer, as well as comparing the drug effectiveness based on deer blood and medicines used in standard treatment regimens. The study was conducted at the ophthalmology and pharmacology departments of VSMU. N. N. Burdenko, "DEER FARM". The group of experimental animals consisted of 30 laboratory rats, which, depending on the treatment were divided into 3 groups. Under the influence of anesthesia, mechanical damage to the corneal epithelium of a laboratory rat was inflicted by a disposable scarifier. Further, the damage diagnosis and the dynamics assessment the process was carried out.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):127-134
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BIOPHARMACEUTICAL ASPECTS OF THE ANTISEPTIC GEL DEVELOPMENT
Bredikhina T.A., Shvedov G.I., Shvedova V.G.
Abstract
An increase in resistant agents of urogenital infections has led to a high demand of novel effective drug development and marketing. Currently the top position in urological and gynecological medication is taken by dosed forms such as suppositories, vaginal pills and capsules. The variety of topical medications, i.e. ointments and gels, is insufficient. In order to broaden the range of topical drugs for the treatment of infectious diseases of the urogenital system, an antiseptic formulation of Miramistin (benzildimethyl [3-(miristoilamino) propyl] ammonium chloride monohydrate) in the form of gel was developed and introduced. The results of a biopharmaceutical study obtained by the method of equilibrium dialysis through a semipermeable membrane were used to select the basic drug composition and to study storage stability of the drug.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):135-139
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REACTIONS DRUG INTERACTIONS WITH COMORBID PATHOLOGY IN ONCOLOGY
Lyakhova N.S., Batishcheva G.A.
Abstract
Antitumor therapy is widely used in the treatment of most cancers. It is used as an independent method, as well as in the combined treatment of cancer pathology. Adequate chemotherapy can improve the quality and increase the life expectancy of cancer patients. Although cardiomyocytes are capable of regeneration, they are susceptible to the effects of chemotherapy drugs, which is manifested by the occurrence of adverse reactions from the cardiovascular system. Сardiotoxicity is most often induced by anthracycline antibiotics and is often potentially dangerous, which impairs the quality of life of cancer patients and increases the cost of treatment for such patients. The issue of primary and secondary prevention of cardiotoxic side effects of chemotherapy is still unresolved, but there is evidence in favor of cardioprotection in the treatment of patients with malignant tumors.
Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). 2019;22(3):140-143
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