Vol 23, No 2 (2020)

The research material was 25 teleradiogram of the heads of patients aged 18-25 with physiological and distal occlusion. The research results showed the absence of statistically significant deviations of morphological parameters from the average values of the norm, which is confirmed by the correlation and regression analysis. A comparative analysis of the results of measurements of the morphological parameters of the dentofacial system of patients with distal occlusion of the dentition obtained with average values of the norm of this age category was carried out.

Several European oral health indicators of forty, proposed by the European Commission Health Monitoring Program (EGOHID-2005) were used in the oral health assessment of 13-year-old children in Voronezh city. The survey data have proved a high validity of indicators for the evaluation and monitoring of oral diseases prevalence and the quality of dental care.

Inflammatory-destructive periodontal diseases are one of the most important challenges in dentistry, while the task of treating and preventing them remains unsolved. In this situation, the most technologically advanced and efficient techniques - ultrasonic scaling for eliminating the main etiological factor of periodontitis - plaque and calculus, - as well as the Vector Fluid polishing device for rehabilitation of periodontal pockets and minimally invasive root resection with hydroxylapatite, are becoming more widespread. In this study, a natural antiseptic - medical ozone - was used as a treatment option for gum recovery instead of conventional antibacterial agents. The study included 93 patients with chronic generalized periodontitis of moderate severity. The results of clinical, laboratory and radiological investigations supported the fact that ultrasound polishing of tooth roots using hydroxylapatite included in the complex therapy with a Vector Fluid polish together with simultaneous antiseptic treatment of periodontal pockets using ozonated water appears to be an effective method of treatment and prevention of periodontitis compared with the conventional approach involving administration of antimicrobial agents.

Modern requirements for biomaterials used as dental implants are due to the need for maximum compliance with the structure, composition and physico-biological properties of native bone. General and applied clinical requirements for selection of materials for implantation are considered. It is emphasized that in each clinical situation, bone defects have their own characteristics related to the etiology, length, general matic status of the patient and other factors. The work on the creation and optimization of existing biomaterials with given properties is now extremely relevant. There are presented clinical examples of use of bioactive obturation systems containing biosteclo, having activity on formation of hydroxyapatite crystals. Maximum quality of sealing and biocompatibility of these materials are confirmed.

The article presents the manufacturing process and the use of a new deprogrammer - an individual mouthguard with a plastic overlay. A clinical example of the application of the proposed device. The use of this apparatus resulted in a decrease in the hypertonicity of the masticatory muscles by dissociating the chewing group of teeth on the central incisors, which resulted in the positioning of the lower jaw in the position of the central ratio, which is confirmed by computed tomography data.

In laboratory conditions, the adhesion strength of light-curing composite materials to dentin of the cervical region of the teeth was determined. Sample preparation and adhesion strength testing was carried out in accordance with ISO 29022:2013 Dentistry - Adhesion - Notched edge shear bond strength test. Significant differences were found in the adhesion strength of the composite material: to mantle dentin in the area of the crown - 34.4±1.27 MPa; in the area of the neck from the vestibular surface at the level of the mantle dentin - 6.7±1.02 MPa; on horizontal sections performed at the level of the neck of the teeth - 2.3±0.94 MPa. With direct composite restoration of teeth with cervical non-carious lesions, it is necessary to apply measures improving the adhesion of the composite material, ensuring a long marginal fit and compensating for the effects of factors that are important in the occurrence of this pathology.

The article presents comparative studies of clinically-oriented properties of materials for the manufacture of temporary fixed structures by direct method: "Tempokor" ("VladMiVa", Russia), "Protemp 4" (ZM ESRE, Germany), "Crown Temp" (TBI Company, Germany), "Tempron"(GC Corporation, Japan) "in vivo". The results of the treatment of 400 patients with the diagnosis " K 03.8 Other specified diseases of hard tissues of the teeth. Defect of hard tissues of teeth". In this study, the papillary-marginal-alveolar index (PMA) was used to assess the degree of inflammatory changes in periodontal tissues. The well-known method of J. C. Green and J. R. Vermillion (1964) was used to determine the oral hygiene index (OHI-S). Damages and violations of fixing of temporary fixed structures were also investigated. The clinical evaluation was conducted in two stages: "at the time of prosthetics" and "14 days after prosthetics with temporary fixed structures".

In laboratory conditions, the strength of the composite material adhesion to the tooth dentin was studied using an adhesive system depending on the method of adhesive preparation. The production of samples and the study of the adhesion strength were conducted in accordance with the ISO 29022:2013 Dentistry - Adhesion - Notched edge shear bond strength test. We used a 5-generation adhesive Gluma 2Bond (Kulzer). 5 variants of adhesive preparation were studied: (1) according to the instructions, (2)" alcohol adhesive Protocol", (3) medical treatment with ethyl alcohol, (4)" chlorhexidine adhesive Protocol", (5) medical treatment with chlorhexidine. A significantly higher strength of adhesion of the composite material to the tooth den-tin was established when using the 5th generation adhesive system according to the instructions (13.5±0.57 MPa) compared to the adhesive preparation in accordance with the "alcohol adhesive protocol" (5.2±0.25, p<0.00001) and "chlorhexidine adhesive protocol" (7.2±0.28 MPa, p<0.00001). The results of the study cast doubt on the information disseminated in social networks regarding the high efficiency and clinical feasibility of using the "spirit adhesive protocol" and the "chlorhexidine adhesive protocol" in practical dentistry. Comprehensive laboratory and clinical research in this area, based on the principles of evidence-based medicine, is necessary.

The analysis of renewal of the assortment of reference medicinal products that passed state registration in 2019 was carried out. The stages of creating a reference drug include not only long-term preclinical and clinical studies, but also a lengthy registration process. Russian legislation, like the legislation of most countries, provides for a simplified procedure for introducing generic medicines into circulation. The study of the range of long-term reference medicines will solve a number of problems both at the level of inventory management of pharmaceutical organizations and in the provision of medicines to the population. The purpose of this work is to analyze the renewal of the assortment of reference drugs for 2019, as well as to study the physical and economic availability of first registered reference medicinal products at the regional level. It was found that the supply of new drugs on the local pharmaceutical market is formed only by 11%, which limits the ability of retail to realize the potential demand of intermediate and final consumers.

Through photocolorimetric research of tyrosine solutions of different concentrations CTyr = 0.2 ÷ 0.5 g /L was verified the possibility of determining the exact concentrations of the amino acid in aqueous solutions by constructing a calibration graph. The conditions of the study (pH of solutions, temperature, time) without the use of aqueous-organic media are clarified. Concentration restrictions for the analysis of tyrosine containing products (plant materials, pharmaceutical products, etc.) are determined.