Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)2070-9277Voronezh State Medical University named after N.N. Burdenko - The State Budgetary Institution of Higher Professional Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Public Health of the Russian932410.18499/2070-9277-2023-26-4-%pPREPARATION AND PROPERTIES OF MICROGEL DISPERSIONS
OF POLY-N-ISOPROPYLACRYLAMIDEShestakovAlexander Sshestakov@chem.vsu.ruKushchevPeter OPeter.kuschev@gmail.comSamotinaIrina Yoap@vrngmu.com2912202326411512208022024Copyright © 2023, Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)2023<p><span lang="EN-US">A series of poly-N-isopropylacrylamide (p-NIPAM) microgels using N,N'-methylenebisacrylamide (0.25, 5.0, and 10.0 mol %) as a cross-linker was obtained by radical precipitation polymerization in an aqueous solutions without using of surfactants. A sample of a cross-linked microgel (5.0 mol.%) was obtained using sodium dodecyl sulfate as an emulgator. The hydrodynamic radius of particles were measured by dynamic light scattering, which amounted to 260400 nm for dispersions obtained in the absence of an emulgator and 145 nm for dispersions obtained in the presence of sodium dodecyl sulfate. The differences can be explained by the processes of adsorption of the emulgator on the surface of polymer particles and the appearance of an electrostatic stability factor. The</span><span lang="EN-US">-potentials of particles were measured by microelectrophoresis, which amounted to -0.84 mV and -6.57 mV for dispersions obtained in the absence and presence of sodium dodecyl sulfate, respectively. This proves the phenomenon of adsorption of the ionic surfactant at the "solution-polymer" interface.Thermoresponsivity curves for the synthesized microgels (heating and cooling) were obtained by dynamic light scattering at the temperature varied from 20 to 45C. The dispersions demonstrate the classical behavior for a thermosensitive microgel, which appears on the graphs as a hysteresis loop.</span></p>microgel, poly-N-isopropylacrylamide, hydrogel, thermosensitivity, biosensors.микрогель, поли-N-изопропилакриламид, гидрогель, термочувствительность, биосенсоры.[1. 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