Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)2070-9277Voronezh State Medical University named after N.N. Burdenko - The State Budgetary Institution of Higher Professional Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Public Health of the Russian931910.18499/2070-9277-2023-26-4-%pAPPLICATION OF FLUORESCENT PROBES AS A PROMISING APPROACH
IN DIAGNOSIS AND THERAPY OF DISEASESKhmelevskayaTatyana Ntatiana_ilinova@mail.ruVandyshevDmitry Yurievichfrancy_2007@mail.ru29122023264838808022024Copyright © 2023, Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)2023<p>Physiological and pathological processes of the body determine the formation of metabolites of a certain composition and concentration, their qualitative and quantitative assessment makes it possible to diagnose the general condition and identify diseases. The currently known methods of instrumental analysis of biosamples are characterized by a number of disadvantages, according to which the search for new test systems is urgent. The article contains information about known biomarkers of diseases, and also evaluates current sensors for diagnosing bioassays. The specific behavior of fluorochrome as an analytical test system is considered. Already existing progress and prospects for the development of the search for new sensors for preclinical and clinical diagnostics are noted.</p>minimally invasive and non-invasive methods, quantum dots, amines.малоинвазивные и неинвазивные методы, квантовые точки, амины.[1. Кокорина Н.О., Новоселов В.П., Ханина М.А. Определение лекарственных препаратов в жидкостях методом высокоэффективной жидкостной хромотографии // Сибирский медицинский журнал. – 2008. - №4. – С. 51-53.][2. Bunge M., Araghipour N., Mikoviny T., Dunkl J., Schnitzhofer R., Hansel A. et al. On-line monitoring of microbial volatile metabolites by proton transfer reaction-mass spectrometry // Applied and environmental microbiology. – 2008. – V. 74, №7. – P. 2179-2186.][3. Filipiak W., Sponring A., Mikoviny T., Ager C., Schubert J., Miekisch, W. Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-1 in vitro // Cancer cell international. - 2012. -V.12, №1. - P. 1-11.][4. Gardenhire D. S., Ely E. W., Massaro A. F., Hess D. R. A guide to aerosol delivery devices for respiratory therapists // American Association for Respiratory Care. – 2018. – 55p.][5. Lemfack M.C., Nickel J., Dunkel M., Preissner R., Piechulla B. mVOC: a database of microbial volatiles // Nucleic Acids Research. 2014. № 42. - P. 744-748.][6. Sethi S., Nanda R., Chakraborty T. Clinical application of volatile organic compound analysis for detecting infectious diseases // Clinical microbiology reviews. -2013. – V. 26, №3. - P. 462-475.][7. Balasubramania M., Sriraman R., Sindhuja P., Mohideen K., Parameswar R.A., Muhamed Haris K.T. Autofluorescence based diagnostic techniques for oral cancer // Journal of Pharmacy and Bioallied Sciences. – 2015. – V.7. - P. 374-377.][8. Jin F., Zhao L. Fluorescence Probe Based on Pyrimidine Applied for Rapid Identification of Different Amino Acids // Russian Journal of Bioorganic Chemistry. – 2023. -V.49. – P. 306–313.][9. Yao H., Zhang Y., Xiao F., Xia Z., Rao J. Quantum dot/bioluminescence resonance energy transfer based highly sensitive detection of proteases // Angewandte Chemie International Edition. – 2007. V. 46, №23. - P. 4346-4349.][10. Wang K., Wang W., Chen X.Y., Yang Y.S. Constructing a novel fluorescence detection method for γ-glutamyltranspeptidase and application on visualizing liver injury // Biosensors and Bioelectronics. – 2022. – V. 219. – P.1-18.][11. Mao G., Du M., Wang X., Ji X., He Z.-K Simple construction of ratiometric fluorescent probe for the detection of dopamine and tyrosinase by the naked eye // Analyst. – 2018. – V.143, №21. - P. 5295-5301.][12. Liu J., Sun Y.Q., Zhang H., Shi H., Shi Y., Guo W. A turn-on fluorescent probe for rapid and selective detection of hydrogen sulfide and its bio-imaging in living cells and mice // Sensors and Actuators B: Chemical. – 2017. -V. 242. - P. 1-7.][13. Yu Z., Zhang J., Chen J., Zhao L., Yu D., Liu L. et. al. A new fluorescent probe tool: ERNathG // Analytical Chemistry. – 2023. -V. 95, № 9. - P. 4261-4265.][14. Huang Y., Qi Yu, Zhan C., Zeng F., Wu S. Diagnosing drug-induced liver injury by multispectral optoacoustic tomography and fluorescence imaging using a leucine- aminopeptidase-activated probe // Analytical Chemistry. – 2019. – V.91, №13. – P. 8085-8092.][15. Zheng B., Pan B., Xu S., Xu Z., Lu G., Wang F. Y., Fang B., Xu C.L. Detection of inflammatory bowel disease (IBD)-associated microRNAs by two color DNA-templated silver nanoclusters fluorescent probes // Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. – 2022. - V.276., № 121185.]