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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)</journal-id><journal-title-group><journal-title>Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)</journal-title></journal-title-group><issn publication-format="electronic">2070-9277</issn><publisher><publisher-name>Voronezh State Medical University named after N.N. Burdenko - The State Budgetary Institution of Higher Professional Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Public Health of the Russian</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">9124</article-id><article-id pub-id-type="doi">10.18499/2070-9277-2023-26-1-9-14</article-id><article-categories><subj-group subj-group-type="heading"><subject></subject></subj-group></article-categories><title-group><article-title>SELECTION OF A STRUCTURAL MATERIAL FOR THE BASIS OF A REMOVABLE PROSTHESIS IN PATIENTS WITH ORAL DYSBIOSIS BASED ON TOXICOLOGICAL EXAMINATION</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Chirkova</surname><given-names>Natalia V.</given-names></name><email>n.v.chirkova@vrngmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Vecherkina</surname><given-names>Zhanna V.</given-names></name><email>dr.zhannet@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Shalimova</surname><given-names>Natalia A.</given-names></name><email>nata-studentstomat@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Primacheva</surname><given-names>Natalia V.</given-names></name><email>nata-studentstomat@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">Voronezh State Medical University</aff><pub-date date-type="epub" iso-8601-date="2023-03-29" publication-format="electronic"><day>29</day><month>03</month><year>2023</year></pub-date><volume>26</volume><issue>1</issue><fpage>9</fpage><lpage>14</lpage><history><pub-date date-type="received" iso-8601-date="2023-07-13"><day>13</day><month>07</month><year>2023</year></pub-date><pub-date date-type="accepted" iso-8601-date="2023-07-13"><day>13</day><month>07</month><year>2023</year></pub-date></history><permissions><copyright-statement>Copyright © 2023, Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)</copyright-statement><copyright-year>2023</copyright-year></permissions><abstract>&lt;p&gt;It is proved that the tissues and organs of the oral cavity are normally in dynamic equilibrium with balanced biochemical processes that preserve tissue structures and support their function. The problem of the relationship of tissues and organs of the oral cavity with materials intended for the manufacture of dentures is one of the main problems in the clinic of orthopedic dentistry. Currently, acrylic plastics, the technological properties of which do not require expensive equipment, are most widely used in the manufacture of prosthetic structures. However, according to most experts, acrylic plastics have a number of significant drawbacks: the occurrence of toxic-allergic reactions, violation of the microflora of the oral cavity, the development of blastomatous growth in the tissues of the prosthetic bed. In order to increase the effectiveness of orthopedic treatment with removable dentures and reduce the intensity of the occurrence and development of oral dysbiosis and inflammatory reactions after prosthetics, the authors conducted biotesting of polymer materials of acrylic nature, the results of which are presented in this paper.&lt;/p&gt;</abstract><kwd-group xml:lang="en"><kwd>orthopedic dentistry</kwd><kwd>dysbiosis</kwd><kwd>removable denture</kwd><kwd>acrylic polymer</kwd><kwd>toxicity</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ортопедическая стоматология</kwd><kwd>дисбиоз</kwd><kwd>съемный зубной протез</kwd><kwd>акриловый полимер</kwd><kwd>токсичность.</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Вечеркина Ж.В., Чиркова Н.В., Пелешенко Е.И., Бобешко М.Н. 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