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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)</journal-id><journal-title-group><journal-title>Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)</journal-title></journal-title-group><issn publication-format="electronic">2070-9277</issn><publisher><publisher-name>Voronezh State Medical University named after N.N. Burdenko - The State Budgetary Institution of Higher Professional Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Public Health of the Russian</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">6754</article-id><article-id pub-id-type="doi">10.18499/2070-9277-2019-22-3-116-120</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>FEATURES OF ANTICOAGULANT THERAPY WITH WARFARIN IN REAL CLINICAL PRACTICE</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Ukolova</surname><given-names>E. A</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Somova</surname><given-names>M. N</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Batischeva</surname><given-names>G. A</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">Voronezh State Medical University</aff><pub-date date-type="epub" iso-8601-date="2019-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2019</year></pub-date><volume>22</volume><issue>3</issue><fpage>116</fpage><lpage>120</lpage><history><pub-date date-type="received" iso-8601-date="2021-04-03"><day>03</day><month>04</month><year>2021</year></pub-date></history><permissions><copyright-statement>Copyright © 2019, Прикладные информационные аспекты медицины</copyright-statement><copyright-year>2019</copyright-year></permissions><abstract>The purpose of this work was to identify the features of the use of warfarin by patients in real clinical practice in outpatient and inpatient settings on the basis of a non-Governmental health care institution "Road clinical hospital at the station Voronezh-1 JSC "Russian Railways". The questions concerning the need for pharmacogenetic testing to personalize the dosage of warfarin study group of patients, as, despite the careful selection of doses of warfarin, a rational combination of it with other drugs, patients compliance with the necessary diets and prescriptions of doctors, almost every second patient has not reached the target level of international normalized ratio (INR).</abstract><kwd-group xml:lang="en"><kwd>Anticoagulant therapy</kwd><kwd>warfarin</kwd><kwd>international normalized ratio</kwd><kwd>thromboembolic complications</kwd><kwd>pharmacogenetic testing</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Антикоагулянтная терапия</kwd><kwd>варфарин</kwd><kwd>международное нормализованное отношение</kwd><kwd>тромбоэмболические осложнения</kwd><kwd>фармакогенетическое тестирование</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Моисеев С.В. 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