Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)2070-9277Voronezh State Medical University named after N.N. Burdenko - The State Budgetary Institution of Higher Professional Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Public Health of the Russian176010.18499/2070-9277-2015-18-1-155-158Original ArticleAN INFLUENCE ON THE PERIPHERAL M-OPIOID RECEPTORS ALTERS THE ACTIVITY OF THESE RECEPTORS IN RAT BRAINSudakovS Ks-sudakov@nphys.ruProskuryakovaT V-ShokhonovaV A-BashkatovaV G-FSS P.K. Anokhin Research Institute of Normal PhysiologyFBGU V.P.Serbsky "Federal Medical Research Centre for Psychiatry and Narcology " the Ministry of Health1505201518115515824042020Copyright © 2015, Прикладные информационные аспекты медицины2015The aim was to study the characteristics of central mu-opioid receptors under peripheral administration of these ligands which does not penetrate the blood-brain barrier. The study of the binding activity of the mu-opioid receptor was determined by radioligand binding assay. The opposite effect of loperamide and naloxone methiodide on density of mu-opioid receptors in the frontal cortex of rats was detected. These findings support the hypothesis on reciprocal interactions between the central and peripheral components of the endogenous opioid systemцентральные и периферические мю-опиоидные рецепторы, радиолигандноое связываниеналоксон метиодилоперамид, гематоэнцефалический барьер1.Судаков С.К., Тригуб М.М. Гипотеза реципрокного взаимодействии центрального и периферического звеньев эндогенной опиоидной системы. //Бюлл. эксперим. биол. и медицины. 2008. Т. 146. № 12. С. 604-607.2.Судаков С.К., Тригуб М.М., Башкатова В.Г. Воздействие на периферические опиоидные рецепторы изменяет морфиновую анальгезию, зависимость и толерантность. //Наркология. 2009. № 11. С. 38-42.3.Судаков С.К., Башкатова В.Г., Колпаков А.А., Тригуб М.М. Периферическое введение лоперамида и метилналоксона подавляет тревожность у крыс/ //Бюл. экспер. биол. мед. 2010. Т. 149. № 3. С. 244-246.4.Chumakova Y.A., Bashkatova V.G., Sudakov S.K. Changes in feeding behavior after peripheral loperamide administration in ratsю // Bull Exp Biol Med. 2011. Vol. 150. № 4. P. 398-400.5.Egleton R.D., Abbruscato T.J., Thomas S.A., Davis T.P. Transport of opioid peptides into the central nervous system. //J. Pharm. Sci. 1998. Vol. 87. № 11. P. 1433-1439.6.Gein S.V. Dynorphins in regulation of immune system functions. //Biochemistry (Mosc). 2014. Vol. 79. № 5. P. 397-4057.Ide S., Sora I., Ikeda K., Minami M., Uhl G.R., Ishihara K. Reduced emotional and corticosterone responses to stress in mu-opioid receptor knockout mice. //Neuropharmacology. 2010. Vol. 58. № 1. P. 241-247.8.Morley J.E., Levine A.S., Yim G.K., Lowy M.T. Opioid modulation of appetite. //Neurosci Biobehav Rev. 1983. Vol. 7. № 2. P. 281-305.9.Rance N.E., Dacks P.A., Mittelman-Smith M.A., Romanovsky A.A., Krajewski-Hall S.J.Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes. //Front Neuroendocrinol. 2013. Vol. 34. № 3. P. 211-227.