Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)2070-9277Voronezh State Medical University named after N.N. Burdenko - The State Budgetary Institution of Higher Professional Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Public Health of the Russian171410.18499/2070-9277-2014-17-2-3-7Original ArticleOXIDATIVE STRESS IN THE PATHOGENESIS OF CEREBROVASCULAR DISEASES AND STROKELutskyM ALustky@vmail.ruVoronezh State Medical Academy151220141723724042020Copyright © 2014, Прикладные информационные аспекты медицины2014The article gives an analysis of the lipid and protein free-radical oxidation (FRO) process as well as the enzymatic and non-enzymatic antioxidant defense systems (ADS) activity accompanied by the oxidative stress formation in cerebrovascular diseases and stroke. The study involved 160 patients divided into 8 clinical groups with different clinical forms of cerebrovascular diseases and types of stroke, and 20 donors as the controls. All the patients had a set of blood tests that evaluated lipid and protein free-radical oxidation intensity values and enzymatic and non-enzymatic antioxidant defense activity indices. A total of 19 parameters and indices were automatically assessed and analyzed; their dynamics made it possible to identify the oxidative stress in one of the links of the complex pathogenesis of cerebrovascular diseases and stroke.окислительный стрессцереброваскулярные заболевания[Луцкий М.А. и др. Окислительный стресс в патогенезе инсульта. Журн. Неврол и психиат (Приложение «Инсульт») 2007; 21: 37-42][Луцкий М.А., и др. Цереброваскулярные заболевания и окислительный стресс. Журн Неврол и психиат (Приложение «Инсульт») 2009; 5: 73-80][Азизова О.А. и др. Взаимосвязь маркеров окислительного стресса с клиническим течением хронической ишемии мозга. Журн Неврол и психиат (Приложение «Инсульт»)][Мазо Г.Э. и др. Воспаление и депрессия: роль окислительного стресса гормональных и клеточных факторах. Журн Неврол и психиат, 2014; 1: 80-84.]