Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)

2070-9277

Voronezh State Medical University named after N.N. Burdenko - The State Budgetary Institution of Higher Professional Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Public Health of the Russian

11567

10.18499/2070-9277-2026-29-1-41-44

Experimental evaluation of osteogenic properties domestic dental materials for replacement of critical defects of bone tissues of the oral cavity

Skachkova

Marina Mikhailovna

Postgraduate student of the Department of Surgical Dentistrymarina.petukhova2014@ya.ruBabieva

Kira Rinatovna

studentbabieva06@bk.ruDyachkova

Ekaterina Yuryevna

Doctor of Medical Sciences, Associate Professor of the Department of Surgical Dentistrydyachkova_e_yu_1@staff.sechenov.ru

FSAEI of HE First MSMU named after I.M. Sechenov of the Russian Ministry of Health (Sechenov University), Institute of Dentistry named after E.V. Borovsky

07042026

2914144

01042026

2026

Introduction. Guided bone regeneration is the primary method for eliminating jaw defects. Autogenous bone has limitations (donor site morbidity, limited volume), which stimulates the search for effective xenogenic substitutes, particularly hydroxyapatite-based materials, including the отечественный product MATRIFLEX. Aim. To evaluate the effectiveness of osteogenesis in critical jaw defects filled with combinations of amorphous hydroxyapatite (HA) and collagen membranes MATRIFLEX in an experimental model. Materials and Methods. The work was carried out at the I.M. Sechenov First Moscow State Medical University (Sechenov University). Four bone defects were created in six rabbits: control (unfilled); HA (Matriflex APATITE); HA + Matriflex DIRECT membrane; HA + Matriflex FIBRO membrane. Edema and hyperemia were assessed on days 7 and 30. Micro-CT and histological examinations were performed on day 90. Results. No significant differences in inflammatory response were observed between groups (p0.05). In the experimental groups, 80100% defect closure was observed compared to the control group. The highest density of regenerated tissue was recorded in the isolated HA group (13,272.61 units). Histologically, fibrous tissue predominated in the control group, whereas in the experimental groups HA integration into newly formed bone was observed. Conclusion. The obtained data confirmed the osteogenic potential of the studied combination and its ability to create optimal conditions for new bone formation, thereby improving the overall effectiveness of the regenerative process.

bone graft material, defect, jaw, hydroxyapatite, collagen, experiment.

костнопластический материал, дефект, челюсть, гидроксиапатит, коллаген, эксперимент.

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