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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)</journal-id><journal-title-group><journal-title>Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)</journal-title></journal-title-group><issn publication-format="electronic">2070-9277</issn><publisher><publisher-name>Voronezh State Medical University named after N.N. Burdenko - The State Budgetary Institution of Higher Professional Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Public Health of the Russian</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">11051</article-id><article-id pub-id-type="doi">10.18499/2070-9277-2025-28-4-79-85</article-id><article-categories><subj-group subj-group-type="heading"><subject></subject></subj-group></article-categories><title-group><article-title>RASPBERRY SHOOTS, PHYTOCHEMICAL STUDY</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Gulyaev</surname><given-names>Dimitri Konstantinovich</given-names></name><bio>&lt;p&gt;к.фарм.н., доцент, доцент кафедры фармакогнозии&lt;/p&gt;</bio><email>dkg2014@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Belonogova</surname><given-names>Valentina Dmitrievna</given-names></name><bio>&lt;p&gt;Doctor of Pharmacy, Professor, Head of the Department of Pharmacognosy&lt;/p&gt;</bio><email>belonogova@pfa.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">Federal State Budgetary Educational Institution of Higher Professional Education of the Ministry of Health of the Russian Federation</aff><pub-date date-type="epub" iso-8601-date="2025-12-27" publication-format="electronic"><day>27</day><month>12</month><year>2025</year></pub-date><volume>28</volume><issue>4</issue><fpage>79</fpage><lpage>85</lpage><history><pub-date date-type="received" iso-8601-date="2026-01-23"><day>23</day><month>01</month><year>2026</year></pub-date></history><permissions><copyright-statement>Copyright © 2025, Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)</copyright-statement><copyright-year>2025</copyright-year></permissions><abstract>&lt;p&gt;The purpose of the work is a phytochemical study of shoots of the first and second years of raspberry to determine the possibility of their use as medicinal plant raw materials.&lt;/p&gt;&#13;
&lt;p&gt;Materials and methods. The objects of the study were samples of young green shoots of the first year and shoots of the second year of raspberry, Rubus idaeus (L.). Raspberry shoots were harvested on the territory of the Ilyinsky district of the Perm Territory. The amount of flavonoids was determined according to a previously developed method. The content of tannins was determined according to the methodology of the State Pharmacopoeia of the Russian Federation of the XV edition, by the premanganometric method. The content of macro and microelements was determined on an X-ray fluorescence, energy dispersion spectrometer.&lt;/p&gt;&#13;
&lt;p&gt;Results. As a result of the study, it was found that flavonoids mainly accumulate in the leaves of raspberries. When comparing the amount of flavonoids in raspberry shoots of the first and second years, it was found that the shoots of the first year contain 2.7 times more flavonoids. Tannins accumulate in greater quantities in the shoots of the first year. Their content in the leaves is higher in comparison with the stem part. The elemental composition of the shoots of the first year has higher values in terms of the content of such important essential elements as iron, magnesium, manganese, titanium, chromium, compared with the shoots of the second year.&lt;/p&gt;&#13;
&lt;p&gt;Conclusion. Due to the higher levels of biologically active substances, the most promising object for harvesting medicinal plant raw materials are young raspberry shoots of the first year.&lt;/p&gt;</abstract><kwd-group xml:lang="en"><kwd>raspberry, shoots of the first year, shoots of the second year, flavonoids, tannins, elements.</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>малина обыкновенная, побеги первого года, побеги второго года, флавоноиды, дубильные вещества, элементы.</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Величко В. В., Макарова Д. Л. Сравнительный фармакогностический анализ листьев и плодов малины обыкновенной. Journal of Siberian Medical Sciences. 2015; 4:16–24. ISSN 2542-1174.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2. Xu Y, Li L.Z., Cong Q, Wang W, Qi X.L., Peng Y, [at al.]. Bioactive lignans and flavones with in vitro antioxidant and neuroprotective properties from Rubus idaeus rhizome. Journal of Functional Foods. 2017;32:160–169. DOI: 10.1016/j.jff.2017.02.022.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>3. Wu L, Liu Y, Qin Y, Wang L, Wu Z. HPLC-ESI-qTOF-MS/MS characterization, antioxidant activities and inhibitory ability of digestive enzymes with molecular docking analysis of various parts of raspberry (Rubus idaeus L.). Antioxidants. 2019;8(9): Art. 274. DOI: 10.3390/antiox8080274.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>4. Oszmianski J, Wojdylo A, Gorzelany J, Kapusta I. Identification and characterization of low molecular weight polyphenols in berry leaf extracts by HPLC-DAD and LC-ESI/MS. Journal of Agricultural and Food Chemistry. 2011;59(24):12830–12835. DOI: 10.1021/jf203052j.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>5. Kashchenko N.I., Olennikov D.N., Chirikova N.K. Metabolites of Siberian raspberries: LC-MS profile, seasonal variation, antioxidant activity and thermal stability of Rubus matsumuranus phenolome. Plants. 2021;10(11): Art. 2317. DOI: 10.3390/plants10112317.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>6. Gesek J, Jakimiuk K, Atanasov A.G., Tomczyk M. Sanguiins—promising molecules with broad biological potential. International Journal of Molecular Sciences. 2021;22(23): Art. 12972. DOI: 10.3390/ijms222312972.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>7. Kobori R, Doge R, Takae M, Aoki A, Kawasaki T, Saito A. Potential of raspberry flower petals as a rich source of bioactive flavan-3-ol derivatives revealed by polyphenolic profiling. Nutraceuticals. 2023;3(2): 196–209. DOI: 10.3390/nutraceuticals3020015.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>8. Kula M, Glod D, Krauze-Baranowska M. Two-dimensional liquid chromatography (LC) of phenolic compounds from the shoots of Rubus idaeus 'Glen Ample' cultivar variety. Journal of Pharmaceutical and Biomedical Analysis. 2016;20(121):99–106. DOI: 10.1016/j.jpba.2015.12.047.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>9. Yang J, Wu L, Wang T, Zhao Y, Zheng X, Liu Y. An integrated extraction–purification process for raspberry leaf polyphenols and their in vitro activities. Molecules. 2023;28: Art. 6321.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>10. Гуляев Д.К., Белоногова В.Д., Коротков И.В. Разработка методики определения содержания флавоноидов в побегах малины обыкновенной. Биофармацевтический журнал. 2023;15(4):35-39. DOI: 10.30906/2073-8099-2023-15-4-35-39.</mixed-citation></ref></ref-list></back></article>
