Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)2070-9277Voronezh State Medical University named after N.N. Burdenko - The State Budgetary Institution of Higher Professional Education «Voronezh State Medical University named after N.N. Burdenko» of the Ministry of Public Health of the Russian1097310.18499/2070-9277-2025-28-2-76-83Comparison of cytokine and antioxidant status of the cornea in thermal and alkaline burnsKirsanovaIrina Vladimirovna<p>Assistant of the Department of Eye Diseases</p>kirsanova-iv@inbox.ruKolesnikovAlexander Vyacheslav<p>Doctor of Medical Sciences, Associate Professor, Head of the Department of Eye Diseases</p>kolldoc@mail.ruMokhovaSvetlana Alekseevna<p>the resident</p>svetlanamohova2000@gmail.comSchulkinAlexey Vladimirovich<p>Doctor of Medical Sciences, Associate Professor, Professor of the Department of Pharmacology</p>alekseyshulkin@rambler.ruRyazan State Medical University named after Academician I.P. Pavlov of the Russian Ministry of Health09112025282768309072025Copyright © 2025, Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny)2025<p>In this study, the free radical status and balance of anti-inflammatory/pro-inflammatory cytokines in corneal tissue with third-degree thermal and alkaline burns were analyzed. The work was performed on 42 rabbits. Manipulations were performed under topical anesthesia. Animals were euthanized on days 1, 3, 5, 7, 14, 21, and 28 after pathology modeling. Each time point included 3 rabbits, 6 eyes. Alkaline burns were caused by applying a filter paper disk soaked in 5% sodium hydroxide solution, and thermal burns were caused by touching with a heated stainless steel cylinder. After the burn, physiological saline was instilled into the conjunctival cavity. The level of TBA-active products, carbonyl derivatives of proteins, SOD activity, the level of TNF-1a, IL-10, IL-4, TGF-1 were assessed in the corneal tissue. Both types of burns were accompanied by the development of oxidative stress and activation of proinflammatory cytokines in the cornea, which confirms the need for similar approaches to treatment. At the same time, some differences were noted in the timing, levels of increase, as well as the rate of normalization of indicators when comparing thermal and chemical damage, which requires further study.</p>alkaline and thermal burns of the cornea, free radical status of the cornea, anti-inflammatory / proinflammatory cytokines.щелочной и термический ожоги роговицы, свободнорадикальный статус роговицы, противовоспалительные/провоспалительные цитокины.[1. Bilalov E.N, Narzikulova K.I, Mirrakhimova S.Sh., et al. Impact of burns and eye injuries on patients’ quality of life (review article) // Western European Journal of Medicine and Medical Science. – 2024. – 2(4):21-26.][2. Kraus H, Filipec M. 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