CARCINOEMBRYONIC ANTIGEN (CEA) AND CA 19-9 LEVELS IN SERUM AND PERITONEAL WASHING AS AN INTRAOPERATIVE PROGNOSTIC MARKER AFTER CURATIVE RESECTION OF GASTRIC CANCER


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Abstract

Analyzed the relationship between levels of tumor markers (carcinoembryonic antigen-CEA and CA 19-9) in the sera and peritoneal washing, and anatomo-pathological aspects of the gastric carcinoma 115 patient with gastric cancer (GC), who treatment in Gomel clinical oncological centre in 2007 y. In 23 events, levels of tumor markers are measured in the tumors extracts. Revealed, inverse correlation to concentrations marker CA 19-9 and CEA in extract of the tumors with differential degree of the tumor (rs = 0,396 and -0,537 accordingly, P<0,05). In ditto time levels of tumor markers in sera and peritoneal washing are connected with their level in extract of the tumors (rs = 0,45 -0,64, P<0,05). As additional significant of the factor is offered use the factor a relations level of tumor markers in peritoneal washing to their level in sera (PW/S), not having statistical significant correlation with contents of the marker in extract of the tumors as for CA 19-9 (rs = 0,19; P=0,37), so and for CEA (rs = 0,05; P=0,81). The high level of the CA 19-9 and CEA in peritoneal washing and increasing of the factor relations concentration CA 19-9 and CEA in peritoneal washing to their concentrations in sera (PW/S) are indicative of the high probability of the development of peritoneal spread - dissemination.
The Frequency of the development last at contents tumor markers within discriminations level and his(its) excess has formed: for CA19-9 in PW - 10,0 and 46,8% (P=0,0005), for relations concentration CA 19-9 in PW/S - 8,3 and 84,4% (P<0,00001), for CEA in PW - 20,5 and 45,3% (P=0,01) and for relations concentration CEA in PW/S - 21,1 and 44,4 % (P= 0,02).

About the authors

A K Al'-Yakhiri

A K Al-Yahairi

Gomel state medical university

Gomel state medical university

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