No 25 (2006)

The results of the investigation of dynamics of the depressive disorder in children with suicidal attempt are presented in the article. Coaxil is shown to be effective in the group, but it is more effective in a complex using with psychotherapy.

44 young men of conscript age with a history of autodestructive behavior (self-harm, not having the goal of depriving themselves of life) were examined by clinical-psychopathological, psychological, statistical and follow-up methods. It is established that most of them - 63.6%, reveal a deformation of the mental warehouse in the form of personality disorders. Mentally healthy make up 31.8%. The motive of self-harming actions in personality disorders was the need to remove autochthonous or psychogenically generated emotional tension, and for mentally healthy persons - the desire to influence the nearest environment or subordination to the "rules of the game". These actions were performed against the background of emotional-volitional immaturity during the period of the physiological pubertal crisis. However, in the subsequent, they critically assessed the perfect act, were well adapted in the microsocial environment, which promoted "emotional-strong- willed ripening" and allowed them to recognize them as mentally healthy and fit for military service with insignificant restrictions.

The authors used the method of drug electrophoresis of 0.5% novocaine solution and 0.5% lidocaine solution in the treatment of closed chest injuries. It was established that physiotherapy methods of anesthesia in patients with thoracic trauma are acceptable at early stages of treatment and allow to achieve optimal analgesia of this category of patients.

It is very important to devise the method allowing to reveal patients with unfavourable (in prognostical aspect) types of the clinical course of Graves’ ophthalmopathy (GO), requiring special attention of endocrinologists and ophthalmologists.

Twenty-six patients with malignant tumors of the adrenal glands were examined, 20 of them were operated. Long-term results of surgical treatment were studied in the period from 2 to 9 years. Patients underwent complex clinical, laboratory and instrumental examination. Adrenocortical carcinomas are more often hormonal-inactive and occur without characteristic clinical manifestations. The use of fine needle aspiration biopsy is justified as a diagnostic method. If the adrenal cancer is suspected of a malignant tumor, an "open" adrenalectomy with a tumor and a dissection of the regional lymph nodes using thoracophrenolumbutic access should be preferred, with adrenal gland suspected of open adrenalectomy using "Mercedes" access. Timely surgical treatment of patients with adrenal tumors is effective, determines the prognosis of the disease and the quality of life.

After carrying out an informational educational work with specialists of various profiles, the number of patients with primary hyperparathyroidism revealed significantly increased. All patients were treated for a long time about the symptomatic complex PGPT in doctors of related specialties, and not about the underlying disease.

The aim of the study was to evaluate the efficacy of various forms of acetylsalicylic acid (ACA) on aggregation activity of platelets in patients with ischemic heart disease: stable angina pectoris with a sensitivity factor to disaggregant therapy (Ra%) and to prove the presence of correlations between biochemical and clinical resistance to ASA 58 patients with stable angina pectoris of II-III FC were observed. ADP-induced platelet aggregation and patient tolerance to exercise were evaluated against the background of administration of Thrombone ACC 50 and ASA 125 mg / day. Criteria for the efficacy of antiplatelet therapy (AAT) using a sensitivity factor for disaggregant therapy (Ra%) and an index of the degree of maximum aggregation (Amax) are proposed. Using these criteria, insufficient sensitivity was found in 34.5% and resistance in 27.6% of patients with Trombo ACC 50, as well as lack of sensitivity in 17.2% and resistance in 20.7% of patients on the background of administration of ASA 125 mg /day. The relationship between the efficacy of AAT and the tolerance of patients to physical activity has been revealed. Thus, the obtained results indicate the validity of the use of the introduced criteria for the effectiveness of AAT (Ra% and Amax) and the presence of correlations between biochemical and clinical resistance to ASA drugs.

The features of the cytokine profile in 120 patients with alopecia areata (GA), aged from 8 to 54 years are considered. The obtained results suggest that in the progressing stage of GA, the cellular part of the immune system plays the leading role, whereas in the stationary stage the changes on the part of the humoral link come to the fore. It is likely that autoimmune processes triggered by the formation of autoreactive clones of cytotoxic lymphocytes leading to hair loss are further supported by immune reactions associated with the production of antibodies. This makes it possible to consider the advisability of including in the complex therapy of GA drugs that reduce the activity of pro-inflammatory cytokines.

Resume: The aim of the research is to evaluate the efficiency of low intensity laser radiation (LILR) in the treatment of rheumatoid arthritis. 70 patients with rheumatoid arthritis were enrolled in the study and allocated into two groups. The patients of group 1 underwent drug therapy and laser therapy, the patients of group 2 - routine pharmacologic therapy. The technique of laser treatment consisted in local subcutaneous irradiation of affected joints. The irradiation was performed using the impulse laser emitting in the infrared wavelength 890 nm. The follow up time was 1 year, during which 3 sessions of laser therapy were carried out. LILR provided modulation in production of some types of T-lymphocytes. The results of the study demonstrate that there is a relationship between the improvements of the clinical findings and immunomodulating effects of LILR. Laser therapy of rheumatoid arthritis appears to exhibit immunomodulating and anti-inflammatory properties.

Resume. The results of the analysis of dynamics of correlational connection between different characteristics of the patients with postdiscectomail syndrome before and after Azaphen treatment are presented in this article. It was revealed that Azaphen treatment during rehabilitation of these patients helps to reduce the level of depression, pain and anxiety disorders.

33 patients of a male with mental retardation who committed criminal aggression and were found insane by the court (7 teenagers from 16 to 18 years and 26 adults from 19 to 52 years) were examined clinico-psychopathologically, clinically-dynamically and statistically. It was found that for the majority of the study population, hereditary burden (oligophrenia or alcoholism of immediate relatives) is characteristic, as well as deviant behavior at school age. In adults with mental retardation, criminal aggression was determined by the presence of a psychopathic syndrome and, often, alcohol intoxication, and in adolescents - by an attempt at rape. High risk of criminal aggression is possessed by persons with the presence of psychopathic syndrome and alcohol intoxication, as well as previously recognized as insane and undergoing compulsory treatment. In the latter case, high tropism was found to commit criminal aggression against relatives. Significant risk factors for criminal aggression (in particular, murder) of persons with mental retardation are family alcoholism and education in the conditions of a children's home-boarding school. Recommendations are offered on complex methods of primary and secondary psycho-prophylaxis.

Resume: As a result of lead by experts of a various structure in ССR, in Russia within 5 years it is established, that in a basis of affective infringements at chronic diseases depressions of a various degree of expressiveness lay mainly. A combination to somatic diseases of depression considerably burden clinical current of chronic somatic diseases, complicate carrying out of rehabilitation and secondary preventive maintenance, worsen quality of a life of patients and negatively influence the forecast.

Resume: Good observability of depressive frustration at patients with chronic diseases is established at carrying out of antidepressive therapy by him. As an energizer of a choice can be used pyrazidoli, possessing enough by high efficiency and the comprehensible price.

The interrelation of infringements of parameters of the immune status at patients with genital herpes infection in a combination with clamidiosis, ureaplasmosis and trichomoniasis and groups of blood is certain. At patients with combined infection transferred sexual by, the highest level immune reactance is established at persons with the third group of blood, the least at pa-tients with the second group of blood. It is revealed, that «contestability» immune parameters on correction derinat and is registered by magneto-infrared-laser influence on decrease in following sequence: patients with group O (I) A (II) B (III).

The antihypoxic effect of new derivatives of oxynicotinic acid on the model of acute hemic hypoxia and in acute anoxia was studied. The experiments were performed on male rats and nonlinear white mice with a mass anaesthetized with ethanal sodium. It was found that the maximum activity close to the activity of sodium oxybutyrate is manifested by the compound under the laboratory code XC-2. In acute anoxia, oxynicotinic acid and its derivatives, with the exception of the connection under the code XC-9, do not have an antihypoxic effect and do not exert a direct activating effect on the bioenergetics of the heart muscle.

Based on the data of our own research, it was found that cough is a frequent manifestation of gastroesophageal reflux disease: 87 (34.8%) of 250 patients with gastroesophageal reflux disease. Tussography combined with a 24-hour esophageal pH-meter made it possible to identify a cough connection with episodes of reflux. Patients with a cough caused by gastroesophageal reflux disease are a heterogeneous group: in 49 of 87 patients the cough was or significantly decreased due to antireflux therapy. The parameters of spectral tusophonobarography were revealed, which can serve as predictors of the insufficient effect of antireflux therapy in patients with cough caused by gastroesophageal reflux disease. In 34 of 38 patients, the insufficient effect of antireflux therapy was due to the presence of eosinophilic inflammation in the bronchi. The administration of beclomethasone dipropionate contributed to a significant reduction in cough in patients with gastroesophageal reflux disease with eosinophilic bronchitis.

Data on the prevalence and types of occupational pathology of industrial workers in Voronezh are given.

The analysis of the ratio of nosological forms and severity of occupational morbidity in the Voronezh region over the past five years is given.

The dynamics of quality of life parameters in patients who underwent microsurgical autotransplantation of vascularized tissue complexes for replacement of defects in the maxillofacial region was studied. It is established that carrying out an operation using the author's method allows to improve the quality of life of this category of patients in the shortest possible time.

The article presents the results of the study of the structural properties of circulating erythrocytes (sorption capacity and osmotic resistance of membranes) in the syndrome of endogenous intoxication. The dependence of the studied characteristics on the degree of severity, the clinical and pathogenetic stage and the nature of the course of this pathological condition was revealed. High specificity of the studied parameters and the pathogenetic validity of this approach allows us to recommend an analysis of the structural properties of red blood cells as markers of endotoxicosis.

В работе обоснована необходимость динамического контроля эффективности и безопасности проводимой гипотензивной терапии у работников железнодорожного транспорта без отрыва от основной производственной деятельности. Наряду с положительным эффектом на проводимое лечение показана возможность развития неблагоприятной реакции в виде ухудшения состояния сердечно-сосудистой системы, напряжения регуляторных систем и оказание неблагоприятного влияния на профессионально значимые функции лиц, связанных с движением поездов.

Resume. The established good supervision of depressive frustration at patients with chronic diseases at carrying out of antidepressive therapy by him pyrazidoli, possessing high bearableness and safety.

The paper presents the results of studies on the study of forest belts on microbiological soil activity (2002-2004). The problems of accumulation of microorganisms in leached chernozems of the Voronezh region are studied. The role of different types of forest belts on the development of microbiological soil activity was revealed.