No 13 (2003)

Pathology of early aged children is characteristic by multiple syndromes, involvement of respiratory system and gastrointestinal tract; dystrophies indicate the necessity of laboratory examination for mucoviscidosis (sweat chlorides, DNA-diagnosis). Pathological and anatomic examination of children, who died from bronchial and pulmonary pathology or/and gastrointestinal syndrome serves the basis for the performance of histological analysis of pancreatic tissues with the aim to search for cystic and fibrous changes.

The examination results have been reported on the incidence rate of purulent meningitis in infants on the territory of Voronezh city according to the data of Regional Pediatric Clinical Hospital No2 for the period of 2000-2003. Etiological factor was compared along with clinical and neurological manifestations and immune status was examined in infants up to 1 year old with purulent meningitis in its acute period. Immunodeficiency condition was identified both in cellular and humoral components, which should be taken into account while administering immunomodulatory therapy.

The Nephrology Unit of Regional Pediatric Clinical Hospital served the basis for life-quality examination in children with chronic urinary diseases, using the adapted questionnaire SF-36. The examination has shown that chronically sick adolescents more often evaluate their health condition as bad compared to their healthy fellows. Teenagers suffering from urinary diseases have considerably higher life-quality parameters, compared to healthy youth, such as pain syndrome intensity (BP), absence of vital energy (VT), limitation in social life (SF), influence of emotional perception on physical activity (RE) and psychological ill-being (MH). The average values of social life limitation level (SF) turned the most different in healthy and sick adolescents, thus one of the major factors of this state was, most likely, the limitation in social life involvement of such teenagers.

The case histories were analyzed of children with the diagnosis either stomach ulcer or chronic erosive gastroduodenitis, treated in Regional Clinical Pediatric Hospital during 2002. It was identified that in modern conditions the rate of duodenum bulb deformation development does not depend on the disease duration, which speaks for the importance of early diagnosis, timely treatment and clinical examination of children and adolescents at the very onset of the disease; differential diagnosis of stomach ulcer and chronic erosive gastroduodenitis is possible only when clinical and anamnestic data are compared to endoscopic examination results. Essential clinical symptoms, indicating that there is high probability of gastrointestinal hemorrhage in acute condition of stomach ulcer, are the presence of positive Mendel’s symptom and the absence of heartburn; the probability rate of gastro-duodenal reflex is increasing with the disease course duration; the efficiency of treatment with tetracycline, semisynthetic penicillin and macrolideis is identical.

It is propose the treatment complex of juvenile metrorrhagia, which based on the researches of structure and the dynamics of mental disturbances and the selection of complex medical of psychotherapy.

The experiment, done on white male rats, exposed to gamma radiation and ethanol, with the use of general histological, neuro-histological and histo-chemical methods, showed up the complex of standard non-specific morpho-functional neurocyte changes; their character and intensity degree depended on effecting factors and the time passing from the exposure termination. It was found that the factors under examination effected neurocytes causing multiple changes in the activity of aerobic tracts of bioenergetic metabolism and alcohol catabolism along with the changes of functional state of hematoencephalic barrier.

Application of video endoscopic techniques during outpatient reception hours in dental surgery unit facilitated greatly the differential diagnosis of paranasal sinus disease, reduced the number of patients appointed inpatient treatment, enabled to decrease traumatism and to raise the rate of patient rehabilitation. Clinically proved combination of conservative treatment methods with endoscopic diagnosis and sparing surgery resulted in stable recovery in the shortest time and in reduction of disability period in patients.

Inclusion of combined postoperative peritoneal cavity sanation into the complex treatment program for general peritonitis increases peritoneal sanation efficiency in postoperative period and thus enables to arrest timely the syndrome of endogenous intoxication, to reduce the number of postoperative complications and to eliminate enteroparesis in the shortest possible time. Inclusion of combined postoperative peritoneal sanation method in the treatment of the main group led to the reduction of mortality rate from 25% down to 17.8%. The data obtained allows that combined postoperative peritoneal sanation method is recommended for inclusion into the complex treatment program for acute peritonitis general forms.

It was identified that reconstructive surgery on aorta and arteries of lower extremities improved considerably the clinical state of patients and increased the life quality parameters according to the scores: physical function, physical role, physical pain and general health condition. Uninterrupted vascular therapy administered in postoperative period ensured the maintenance of good surgery results and life quality enhancement according to the scores: physical pain and physical and emotional role.

Generalizing the results of experimental research conducted, it is worth noting that all the working media of the studied synthetic surface-active substances recommended by the All-Union Research Fire Extinguishing Institute of the USSR Ministry of Internal Affairs may be used in practice by the officers of fire fighting services, still if the mentioned concentrations of the working media are not observed or exceeded in conditions of long-term contact with them, the studied foam solutions may cause the marked changes of major vital functions of an organism. They may pollute the atmospheric air in very vast area, drinking water, soil and plants growing on it.

Major characteristics of medico-social characteristics of metallurgical industry workers and employees include the prevalence of male personnel aged 40 years old and more, having vocational education; work in three shifts; moderate manual labor; presence of adverse sanitary and hygienic work conditions such as noise, vibration, high humidity and poor lighting; smoking and alcohol drinking habits in overwhelming majority of workers; married status, self-assessment of own health condition as “good”, still medical examination showed that most of them needed regular medical check-up on account of digestive diseases and concomitant illness.

Full left bundle-branch block completely conceals ECG features of acute cardiac infarction and directly affects the course, development of complications and clinical picture. Enzymatic diagnosis, particular, Troponin-diagnosis, was suggested to diagnose cardiac infarction against the background of full left bundle-branch block.

460 patients with chronic obstructive pulmonary diseases of different severity degree underwent examination. basing on the mathematical analysis of examination results clinical hemodynamic groups were selected, reflecting the stages of pathological process development and condition severity in patients; algorithms were developed as well to evaluate statistical tendencies of parametric changes in the course of drug therapy. The emphasis was made on the study of relationships between hemodynamic disorders, lipid peroxidation, bioenergetic processes, heart rate variability and hormonal disorders during aggregation of chronic obstructive pulmonary disease. It was found that severity increase of chronic obstructive pulmonary disease led to the intensity growth of free radical processes against the background of progressive antioxidant system insufficiency; activation of intracellular glycolytic processes in erythrocytes, indicating the growing bioenergetic insufficiency, disturbance of vegetative regulation of heart rate with sympathetic influence prevailing. The algorithm was proved for antioxidant treatment combined with calcium channel blockers at different stages of chronic cor pulmonale development.

Microflora composition and its virulence were examined in patients with acute destructive pyelonephritis along with the influence of ozonized solutions on pathogenic microflora. The data received show high efficiency of ozone application in the complex treatment of patients with acute destructive pyelonephritis.

93 children under 3 years old with acute diarrhea were kept under medical observation. The patients had complex checkup, which included examination of immune status and parameters of gastrointestinal tract functioning (coprocytogram, number of lacto- and bifidobacteria, content of fecal carbohydrates and fecal pH). New domestic medicine Bifilactrin was administered to treat acute diarrheal diseases. Comparative assessment of different therapeutic methods was made using new probiotic Bofodumbacterin and antibacterial drugs. The administration of double-culture probiotic was proved to have clinical and laboratory efficiency in the treatment of acute intestinal infections of light and moderate severity degree.