No 53 (2013)

The anxiety and depressive disorders correction using agomelatine was carried out in order to explore the possibility to improve the clinical course of type 2 diabetes in 94 patients within 1 month. With the help of HADS found significant decrease in the degree of anxiety and depression from 10 days of treatment. Patients treated with agomelatine, noted a more rapid and significant improvement in clinical symptoms of diabetes and carbohydrate metabolism compensation.

The article gives an analysis of a number of parameters indicating that there cannot be any isolated disorders in a human organism. Immune system abnormalities are closely related to nervous and endocrine regulations of functions. Immunopathology, in its turn, is associated with metabolic disorders, which finally lead to additional complications. There exists a real capacity in a patient’s organism to influence the immune status by means of biochemical parameters and vice versa. All these aspects are analyzed in the given article.

Caries is the most wide-spread human sickness of the world. The results of researches devoted the diagnostic, treatment and prophylaxis of pathology and recurrence pathology of hard teeth tissues is the so important for all dentists and patients. The most prevalent method of caries treatment is the direct composite (resin) restoration of cavity decay. The next important problem in direct composite restoration is edge adaptation of different composites because there are not the chemical connections between the composite and human enamel and dentine. It has been proved the existence of a previously unknown structural of enamel, so-called enamel tunnels and enamel bridges, by studying enamel ultra structure using atomic force microscopy (Solver P47 device). The surface of enamel was estimated by four criteria’s - phase, cross section, topography and 3D reconstruction. The two morphological conditions of enamel hydroxyapatites was indicated - nano crystal and poly crystal forms. Based on the new understanding of the microstructure of the enamel by means of heterophase and homophase doping with water mix of carbon nano tubes, micro filled hybrid composite material it was obtained a new dental nano composite, the application of which, after appropriate clinical tests can significantly improve the effectiveness of treatment caries in preventing its recurrence. We used the two kinds of doping - surface and volume. It has been proved the existence of new composite properties, by studying composite surfaces and ultra structure using scanning electron microscopy (Jeol device).

The article gives a detailed analysis of protein and lipid free-radical oxidation processes identifying oxidative stress in Primary Progressive Multiple Sclerosis (PPMS) and Secondary Progressive Multiple Sclerosis (SPMS). The findings obtained in the course of the study make it possible to verify the presence of two factors in the oxidative stress development, namely: the intensification of free-radical oxidation (FRO) processes and the functional imbalance in the enzymatic and nonenzymatic segments of the antioxidant defense system (ADS) in PPMS and SPMS. The understanding of the complex pathogenesis of Multiple Sclerosis guarantees an effective and potentially productive therapy for such a severe disease of the nervous system.

The expression of immunohistochemical markers of proliferative activity of Ki-67 and anti-apoptosis Bcl-2 in gunshot injuries, which are less than 1 hour. Shows significant differences in the level of expression of antigens for different types at the same old injury. Proposed to use the expression level of anti-apoptosis and proliferation markers as additional criteria in determining the remoteness of gunshot injuries.