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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)</journal-id><journal-title-group><journal-title>Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)</journal-title></journal-title-group><issn publication-format="electronic">1990-472X</issn><publisher><publisher-name>Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">7998</article-id><article-id pub-id-type="doi">10.18499/1990-472X-2022-0-90-32-35</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>PREDICTION OF THE RISK OF THE DEVELOPMENT OF REPEATED UNSTABLE ANGINA: THE ROLE OF MARKERS OF ENDOTHELIAL DYSFUNCTION AND OXIDATIVE STRESS</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Voronin</surname><given-names>N. I</given-names></name><bio></bio><email>-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kotova</surname><given-names>Yu. A</given-names></name><bio>Department of Clinical Laboratory Diagnostics</bio><email>-</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Semikolenova</surname><given-names>V. A</given-names></name><bio>Department of Clinical Laboratory Diagnostics</bio><email>-</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Lagutina</surname><given-names>S. N</given-names></name><bio>Department of Clinical Laboratory Diagnostics</bio><email>-</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff id="aff-1">TGU im. G.R. Derzhavina</aff><aff id="aff-2">Voronezh State Medical University</aff><pub-date date-type="epub" iso-8601-date="2022-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2022</year></pub-date><issue>90</issue><fpage>32</fpage><lpage>35</lpage><history><pub-date date-type="received" iso-8601-date="2023-01-22"><day>22</day><month>01</month><year>2023</year></pub-date></history><permissions><copyright-statement>Copyright © 2022, Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)</copyright-statement><copyright-year>2022</copyright-year></permissions><abstract>Ischemic heart disease is a common pathology leading to high mortality rates worldwide. One of the manifestations of this condition is unstable angina, which is often repeated. As a result, it is necessary to develop new approaches for assessing the functional state of patients with coronary heart disease. One of the promising methods for timely diagnosis is to identify a direct relationship between such blood parameters as endothelin-1, ADMA and ADPGn and the likelihood of developing unstable angina pectoris.</abstract><kwd-group xml:lang="en"><kwd>unstable angina pectoris</kwd><kwd>cardiovascular disease</kwd><kwd>endothelin-1</kwd><kwd>recurrent coronary events</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>нестабильная стенокардия напряжения</kwd><kwd>сердечно - сосудистая патология</kwd><kwd>эндотелин-1</kwd><kwd>повторные коронарные события</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Relationship between indices of oxidative stress, endothelial dysfunction and chaperone activity and the severity of coronary atherosclerosis / Котова Ю.А., Зуйкова А.А., Пашков А.Н., Страхова Н.В., Красноруцкая О.Н // International Journal of Biomedicine. - 2018. - Т. 8. - No. 3. - С. 182-185.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Оценка прогностического значения маркеров окислительного стресса в формировании клинической картины перинатального поражения центральной нервной системы у детей первого года жизни / Романова М.М., Балакирева Е.А., Красноруцкая О.Н., Бугримов Д.Ю., Котова Ю.А., Страхова Н.В., Ануфриева Е.И // Современные проблемы науки и образования. - 2016. - No. 5. - С. 85.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>COVID-19 and cardiovascular diseases: from epidemiology to rehabilitation / Bubnova M.G., Aronov D.M. // Pulmonology. - 2020. - No. 5. - pp. 688-699.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Стабильная ишемическая болезнь сердца / Акчурин Р.С., Алекян Б.Г., Аронов Д.М // Российский кардиологический журнал. - 2020. - No. 5. - С. 25.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Веприцкая Е.В. 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