Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)1990-472XФедеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации784210.18499/1990-472X-2022-0-88-93-102Original ArticleANTIVIRAL ANTIBODIES AND IMMUNE STATUS OF PATIENTS WITH ANXIETY-DEPRESSIVE DISORDERSZemskovA. M-BakulinaN. I-ShiryaevO. Yu-PeleshenkoE. I-KostenkoS. M-ZemskovaV. A-28092022889310227092022Copyright © 2022, Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)2022A study was performed on the presence of antibodies against Epstein-Barr viruses, herpes simplex, cytomegalovirus in persons suffering from anxiety-depressive disorders. Pronounced changes in immunological parameters in this contingent from the level of practically healthy volunteers are shown. The dependence of quantitative and qualitative variations of immunological indicators, their correlation relationships on the type of carrying antiviral antibodies by patients has been established. It has been established that in patients with anxiety-depressive disorders, the carriage of antiviral antibodies against EBV occurs in each of the patients we studied, the combination of EBV, HSV and CMV antibodies is 70.5%, the combination of antibodies to EBV and HSV in 85.3% of cases, the combination of antibodies to EBV and CMV in 82.4% of cases.anxiety-depressive disordersvirusesantibodiesimmunological disordersтревожно-депрессивные расстройствавирусыантителаиммунологические расстройства1.Земсков А.М., Есауленко И.Э. Курс лекций по клинической иммунофизиологии. Воронеж. Изд. Ритм, 2017. - 1048 с. @@Zemskov AM, Esaulenko I.E. 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