Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)

1990-472X

Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации

7632

10.18499/1990-472X-2021-0-86-18-23

Original Article

THE LEUKOGRAM ENTROPY IN COVID-19

Grebennikova

I. V

-Makeeva

A. V

-Lidokhova

O. V

-Bolotskikh

V. I

-Berdnikov

A. A

-Savchenko

A. P

-Blinova

Yu. V

Voronezh State Medical UniversityVoronezh Regional Children's Clinical Hospital №1

15122021

861823

11052022

2021

The assessment of body adaptation level was carried out according to the integral indicators of peripheral blood for 210 Covid-19 patients aged from 25 to 86 years. One of the methods for hemogram integral evaluation is the calculation of human leukogram entropy. The values of absolute and relative leukogram entropy of patients with coronavirus infection at admission and discharge were studied in comparison with normal (reference) values. The change in entropy was assessed as a maladaptive state of the organism. A significant increase in these indicators was found in dynamics (at admission, the absolute entropy was 1.16 ± 0.26 and at discharge 1.30± 0.20; the relative entropy was 50.11±11.25% and 56.17± 8.73%, respectively, p <0.01). The dependence between leukogram entropy and erythrocyte sedimentation rate (r=-0.16, p<0.05) was revealed. Thus, the information leukogram entropy allows, along with other laboratory indicators, to apply it in clinical practice as methods for assessing the severity of Covid-19 disease.

Covid-19entropyleukocyte blood countCovid-19human leukogram entropy

энтропиялейкоцитарная формула кровиинформационная энтропия лейкоформулы

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