Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)1990-472XФедеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации664910.18499/1990-472X-2020-0-81-31-33Original ArticleCLINICAL AND PATHOGENETIC VALUE OF NEUROPEPTIDE Y IN PATIENTS WITH BRONCHIAL ASTHMAShkatovaYa. S-BudnevskyA. V-TribuntsevaL. V-ProzorovaG. G-Voronezh State Medical University1512202081313316032021Copyright © 2020, Научно-медицинский вестник Центрального Черноземья2020Bronchial asthma is a widespread disease that leads to poor quality of life and disability; this disease affects 300 million people worldwide. In recent years, interest has arisen in the nature of the relationship between neuropeptide Y (NPY) and asthma, since certain NPY genotypes are associated with asthma, NPY Y1 receptors are likely to play an important role in allergic airway inflammation, and during exacerbations of asthma, NPY levels can rise. Thus, the aim of the study was to identify the relationship between the level of neuropeptide Y and the features of the clinical course of asthma.neuropeptide Ybronchial asthmaleptinadiponectinobesityнейропептид Yбронхиальная астмалептинадипонектиножирение1.Braman S.S. The global burden of asthma. Chest. 2006;130(1 Suppl):4S-12S. DOI: 10.1378/chest.130.1_suppl.4s.2.Chung KF. Clinical management of severe therapy-resistant asthma. Expert Rev Respir Med. 2017 May;11(5):395-402. doi: 10.1080/17476348.2017.1317597.3.Lu Y., Andiappan A.K., Lee B., et al. Neuropeptide Y associated with asthma in young adults. Neuropeptides. 2016;59:117-121. DOI: 10.1016/j.npep.2016.07.003.4.Jaakkola U., Kakko T., Juonala M., et al. Neuropeptide Y polymorphism increases the risk for asthma in overweight subjects; protection from atherosclerosis in asthmatic subjects--the cardiovascular risk in young Finns study. Neuropeptides. 2012;46(6):321-8. DOI: 10.1016/j.npep.2012.09.005.5.Macia L., Rao P.T., Wheway J. et al. Y1 signalling has a critical role in allergic airway inflammation. Immunol Cell Biol. 2011;89(8):882-8. DOI: 10.1038/icb.2011.6.6.Cardell L.O., Uddman R., Edvinsson L. Low plasma concentrations of VIP and elevated levels of other neuropeptides during exacerbations of asthma. Eur. Respir. J. 1994;7(12):2169-73. DOI: 10.1183/09031936.94.07122169.