Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)1990-472XФедеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации464310.18499/1990-472X-2014-0-55-3-8Original ArticleANALYSIS OF PROTEIN AND LIPID FREE-RADICAL OXIDATION PROCESSES UNDER NORMAL AND PATHOLOGICAL CONDITIONSLutskyM ALustky@vmail.ruSmelyanetsM A-Voronezh State Medical Academy15032014553825042020Copyright © 2014, Научно-медицинский вестник Центрального Черноземья2014The article analyzes the role of free-radical oxidation (FRO) in the metabolism of cells; it is supposed to be one of the most important regulators of the metabolism serving as the basis for plastic and energetic maintenance of cells and the organism as a whole. The author puts emphasis on the significant role of FRO processes in the regulation of cell proliferation intensity as well as in the prostaglandins and catecholamines biosynthesis. Free-radical oxidation is a typical chain process with a degenerated branching proceeding by the free-radical mechanism in several stages. The multistage degradation of polyunsaturated lipids in free-radical reactions results in the formation of a range of primary, secondary, and end molecular products, which play an important role in the structural modifications of biomembranes and their physical-chemical properties changing. Any cell in the organism possesses constant conditions for FRO processes due to the presence of substrates (lipids and proteins), initiators and catalysts: reactive oxygen species and transition metal ions. At the same time, the content of free-radical oxidation products under normal conditions is not high. This is achieved through the continuous complex of biological mechanisms of the antioxidant defense system (ADS). The antioxidant defense system restricts the lipid and protein free-radical oxidation process at practically all stages and maintains the reactions at the relatively constant level. Free-radical reactions, which involve lipids and proteins under normal conditions, act as a nonspecific, pathogenic factor in pathologies initiating so-called «free-radical pathology» or oxidative stress. The intensification of free-radical oxidation processes as well as the antioxidant imbalance are the main signs of oxidative stress.free-radical oxidationoxidative stressсвободнорадикальное окислениеокислительный стресс1.Рассеянный склероз: избранные вопросы теории и практики.Под ред. И.А. Завалишина, В.И. Головкина. М 2000.-639 с.2.Гусев Е.И. Ишемия головного мозга / Е.И. Гусев, В.И. Скворцова.- М.: Медицина, 2001.- 376 с.3.Виленский Б.С. Инсульт: профилактика, диагностика и лечение / Б.С.Виленский. - СПб: Фолиант, 2002. -398 с.4.Скворцова В.И. Механизмы повреждающего действия церебральной ишемии и новые терапевтические стратегии / В.И.Скворцова // Журнал невропатологии и психиатрии.-2003.-№9.- С.20-25.5.Шмидт Т.Е. Рассеянный склероз/Т.Е. Шмидт, Н.Н. Яхно. - М.: Медицина, 2003. - 156 с.6.Рассеянный склероз и другие демиелинизирующие заболевания/ под ред. Е.И. Гусева, И.А. Завалишина, А.Н. Бойко. - М., 2004. - 528 с.7.Луцкий М.А. Активность эндогенной системы антиоксидантной защиты организма// Луцкий М.А. и др. Системный анализ и управление в биомедицинских системах. Журнал практической и теоретической биологии и медицины. Т. 9, №2. - Москва. - 2010. - С.281-284.8.Ken Uchino, Jennifer K.Pary, James C. Grotta. Acute Stroke Care/ Перевод с англ. под ред. чл.-кор. РАМН В.И. Скворцовой. - М.: ГЕОТАР-Медиа, 2009. - 232 с.