Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)1990-472XФедеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации460610.18499/1990-472X-2013-0-52-146-155Original ArticleMORPHOLOGICAL ANALYSIS OF POPULATIONS MAST CELLS IN THE STROMA IN PATIENTS WITH FIBROCYSTIC DISEASE AND BREAST CANCERMnihovichMV V-GavrilyukAA-FominaLV V-GuminskiySV I-VernigrodskiyS V-TernovMM M-MiglyasVG G-Scientific-Research Institute of Human MorphologyVinnitsa National Medical UniversityMedical Faculty of Uzhgorod National University151220135214615525042020Copyright © 2013, Научно-медицинский вестник Центрального Черноземья2013Morphological, ultrastructural and functional characteristics biptatov breast tumors obtained during surgery in 158 patients aged 26 to 82 years. Since preoperative diagnosis in 73 patients with fibrocystic disease, 46 - fibroadenoma in 23 - infiltrating ductal carcinoma and 16 patients diffuse fibroadenomatosis. tumor sizes ranged from 1.0 to 7.9 cm in diameter. The study demonstrates the active role of TK systems for all types of breast pathology studied. This activation is dynamic, is cyclical and depends on the type of tumorмолочная железафиброзно -кистозная болезньморфологическое исследованиетучные клетки[1. Быков В.Л. Секреторные механизмы и секреторные продукты тучных клеток // Морфология. 1999. Т. 115, № 2. С. 64-72.][2. Быков В.Л. Развитие и гетерогенность тучных клеток // Морфология. 2000. Т. 117, № 2. С. 86-92.][3. Acikalin M.F., Oner U., Topçu I. et al. Tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas // Dig. Liver Dis. 2005. Vol. 37 (3). P. 162-169.][4. Baram D. Human mast cells release metalloproteinase-9 on cont with activated T cell: juxtacrine regulation by TNF-alpha // J. Immunol. 2001. Vol. 167 (7). P. 4008-4016.][5. Burcin Tuna, Kutsal Yorukoglu, Mehtat Unlu et al. Association of mast cells with microvessel density in renal cell carcinomas // Eur. Urology. 2006. Vol. 50 (3). P. 530-534.][6. Carlini M.J., Dalurzo M.C., Lastiri J.M. et al. Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance // Hum. Pathol. 2010. Vol. 41 (5). P. 697-705.][7. Caruso R.A., Ieni A., Fabiano V.C. et al. Perivascular mast cells in advanced gastric adenocarcinomas: an electron microscopic study // Anticancer Res. 2004. Vol. 24 (4). P. 2257-2263.][8. Ch’ng S., Wallis R.A., Yuan L. et al. Mast cells and cutaneous malignancies // Mod. Pathol. 2006. Vol. 19 (1). P. 149-159.][9. Chan J.K., Magistris A., Loizzi V. et al. Mast cell density, angiogenesis, blood clotting, and prognosis in women with advanced ovarian cancer // Gynecol. Oncol. 2005. Vol. 99 (1). P. 20-25.][10. Chugunova E. Biological Function of Mast Cell Chymase. In vitro and in vivo studies: a thorny pathway // Doctoral thesis Swedish University of Agricultural Sciences Uppsala. 2004.][11. Conti P., Castellani M.L., Kempuraj D. et al. Role of mast cells in tumor growth // Ann. Clin. Lab. Sci. 2007. Vol. 37 (4). P. 315-322.][12. Crivellato E., Nico B., Ribatti D. Mast cell contribution to tumor angiogenesis: a clinical approach // Eur. Cytokine Netw. 2009. Vol. 20 (4). P. 197-206.][13. Crivellato E., Nico B., Ribatti D. Mast cells and tumour angiogenesis: new insight from experimental carcinogenesis // Cancer Lett. 2008. Vol. 269 (1). P. 1-6.][14. Dundar E., Oner U., Peker B.C. et al. The significance and relationship between mast cells and tumor angiogenesis in non-small cell lung carcinoma // J. Int. Med. Res. 2008. Vol. 36 (1). P. 88-95.][15. Galinsky D.S., Nechushtan H. Mast cells and cancer-no longer just basic science // Crit. Rev. Oncol. Hematol. 2008. Vol. 68 (2). P. 115-130.][16. Galli S.J. Mast cells and basophils // Curr. Opin. Hematol. 2000. Vol. 7 (1). P. 32-39.][17. Grizzi F., Franceschini B., Chiriva-Internati M. Mast cells and human hepatocellular carcinoma // World J. Gastroenterol. 2003. № 9. P. 1469-1473.][18. Johansson A., Rudolfsson S., Hammarsten P. et al. Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy // Am. J. Pathol. 2010. Vol. 177 (2). P. 1031-1041.][19. Kasacka I., Sawicki B., Roszkowska-Jakimiec W. Immunohistochemical evalution of mast cell and mark activity tryptase and chymase in experimental fibrosarcoma // Ann. Ac. Med. Bialostocensis. 2004. Vol. 49 (1). P. 61-63.][20. Kwon G.Y., Lee S.D., Park E.S. Mast cell and macrophage counts and microvessel density in invasive breast carcinoma-comparison analysis with clinicopathological parameters // Cancer Res. Treat. 2005. Vol. 37 (2). P. 103-108.][21. Mohtasham N., Babakoohi S., Salehinejad J. et al. Mast cell density and angiogenesis in oral dysplastic epithelium and low- and high-grade oral squamous cell carcinoma //Acta Odontol. Scand. 2010. Vol. 68 (5). P. 300-304.][22. Moon T.C., Laurent C.D., Morris K.E. et al. Advances in mast cell biology: new understanding of heterogeneity and function // Mucosal. Immunol. 2010. Vol. 3 (2). P. 111-128.][23. Utrera-Barillas D., Castro-Manrreza M., Castellanos E. et al. The role of macrophages and mast cells in lymphangiogenesis and angiogenesis in cervical carcinogenesis // Exp. Mol. Pathol. 2010. Vol. 25. P. 5-11.][24. Varayoud J., Ramos J.G., Bosquiazzo V.L. et al. Mast cells degranulation affects angiogenesis in the rat uterine cervix during pregnancy // Reproduction. 2004. Vol. 127 (3). P. 379-387.][25. Wilk M., Liszka Ł., Paleń P. et al. Intensity of angiogenesis and mast cell infiltration in cervical intraepithelial and invasive lesions - are they correlated? // Pathol. Res. Pract. 2010. Vol. 206 (4). P. 217-222.][26. Woldemeskel M., Rajeev S. Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors // Vet. Res. Commun. 2010. Vol. 34 (2). P. 153-160.][27. Yano H., Kinuta M., Tateishi H. et al. Mast cell infiltration around gastric cancer cells correlates with tumor angiogenesis and metastasis // Gastric Cancer. 1999. Vol. 2 (1). P. 26-32.]