Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)1990-472XФедеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации2110.18499/1990-472X-2018-0-71-93-96Original ArticleSTUDY OF THE EFFECT OF NO-SYNTHASE INHIBITOR ON PARAMETERS OF ANXIETY AND PAIN SENSITIVITY UNDER LONG LASTING PRENATAL ADMINISTRATION OF CAFFEINEBashkatovaV G-BogdanovaN G-AlexeevaE V-NazarovaG A-SudakovS K-P.K. Anokhin Research Institute of Normal Physiology1503201871939603022020Copyright © 2018, Научно-медицинский вестник Центрального Черноземья2018The influence of inhibitor of nitric oxide synthase (NO) on anxiety and pain sensitivity of rats aged 35-45 days under long lasting prenatal administration of caffeine was studied. It was found that prenatal administration of caffeine reduced pain sensitivity, but did not influenced on level of anxiety in rats. Preliminary administration of NO synthase inhibitor induced analgesic and anxiolytic effects in rats treated prenatally, both caffeine and water.nitric oxideanxietyanalgesic effectprenatal actionratscaffeineоксид азотатревожностьанальгетический эффектпренатальное воздействиекрысыкофеин1.Curran C.P., Marczinski C.A. Taurine, caffeine, and energy drinks: Reviewing the risks to the adolescent brain. Birth Defects Reserach. 2017; 109(20):1640-1648.2.Судаков С.К., Башкатова В.Г. Некоторые аспекты нейрохимических эффектов кофеина. Наркология. 2015; 14(6):72-78.3.Imam S.Z., Islam F., Itzhak Y., Slikker W. Jr., Ali S.F. Prevention of dopaminergic neurotoxicity by targeting nitric oxide and peroxynitrite: implications for the prevention of methamphetamine-induced neurotoxic damage. Annals of New York Academy of Sciences. 2000;914:157-71.4.Bashkatova V., Mathieu-Kia A.-M., Durand C., Penit-Soria J. Neurochemical changes and neurotoxic effects of an acute treatment with sydnocarb, a novel psychostimulant comparison with d-amphetamine. Annals of New York Academy of Sciences. 2002; 965:180-192.5.Downey L.A., Loftis J.M. Altered energy production, lowered antioxidant potential, and inflammatory processes mediate CNS damage associated with abuse of the psychostimulants MDMA and methamphetamine. European Journal Pharmacology. 2014;727:125-129.6.Ferré S., Orrú M., Guitart X. Paraxanthine: Connecting Caffeine to Nitric Oxide Neurotransmission. Journal of Caffeine Research. 2013;3(2):72-787.Abekawa T., Ohmori T., Honda M., Ito K. Koyama T. Effect of low doses of L-NAME on methamphetamine-induced dopaminergic depletion in the rat striatum. Journal of Neural Transmission (Vienna). 2001;108(11):1219-1230.8.Bashkatova V., Rayevsky K., Kraus M., Prast H., Philippu A., Vanin A. Influence of NOS inhibitors on changes in Ach release and NO level in the brain elicited by amphetamine neurotoxicity. NeuroReport. 1999;10(15): 3155-3158.9.Pellow S, Chopin P., File E., Briley M. J. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Neuroscience Methods. 1985;14(3);149-167.10.Бондаренко Д.А., Дьяченко И.А., Скобцов Д.И., Мурашев А.Н. In vivo модели для изучения анальгетической активности. Биомедицина. 2011;2:84-94.