Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)1990-472XФедеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации1101410.18499/1990-472X-2025-26-3-80-85Difficulties in diagnosing juvenile dermatomyositisKondratiefaInna Vladislavovna<p>PhD, Associate Professor of the Department of Hospital Pediatrics</p>innakondrateva6121@yandex.ruZakirovMarat Magdamovich<p>Head of the Cardiorheumatology Department</p>maratzak3@mail.ruZhitenevaAnastasia Ivanovna<p>pediatric cardiologist, rheumatologist of the cardioreumatological department</p>zhiteneva.anastasia@mail.ruTishkinaSvetlana Andreyevna<p>Resident of the Department of Hospital Pediatrics</p>tishkinasvetlana1201@mail.ruN.N. Burdenko Voronezh State Medical University of the Russian Ministry of HealthBUZ VO VOKDKA No. 1, Voronezh10112025263808502102025Copyright © 2025, Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)2025<p>Juvenile dermatomyositis is a rare systemic disease of autoimmune etiology characterized by damage to small vessels of the skin, skeletal muscles, and internal organs, which manifests itself as symmetrical weakness of the proximal muscles and a characteristic rash. The article describes a 9-year-old boy with clinical features of juvenile dermatomyositis and normal values of creatine phosphokinase, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase. According to electroneuromyography, a decrease in the amplitude of M-responses was noted. Significant clinical improvement was observed after one week from the beginning of immunosuppressive therapy. The presented clinical case shows that juvenile dermatomyositis is a difficult-to-diagnose disease that can occur with normal levels of muscle breakdown enzymes</p>juvenile dermatomyositiscreatine phosphokinaseaspartate aminotransferasealanine aminotransferase.ювенильный дерматомиозиткреатинфосфокиназааспартатаминотрансферазааланинаминотрансфераза1.1. Подчерняева, Н. С., Коневина, М. С., Тихая, М. И. Ювенильный дерматомиозит: современные представления. Часть 2: оценка активности и лечение // Педиатрия. — 2019. — Т.98. – № 5. — С. 135-146. DOI: 10.24110/0031-403X-2019-98-5-135-1462.2. Клинические рекомендации. Ювенильный дерматомиозит. 2017. – Текст : электронный // Союз педиатров России: официальный сайт. – URL: https://www.pediatr-russia.ru/information/klin-rek/deystvuyushchie-klinicheskie-rekomendatsii/Ювенильный_дерматомиозит_КР480.pdf (дата обращения: 30.06.2025).3.3. Lundberg I.E., Tjärnlund A., Bottai M. et al. European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups // Arthritis & Rheumatology. — 2017. — Vol. 69, № 12. — P. 2271–2282. — DOI: 10.1002/art.40320.4.4. Мамедова С. Н., Мусаев С. Н. Трудности ранней диагностики ювенильного дерматомиозита: краткий обзор литературы и клинический случай // Астраханский медицинский журнал. — 2023. — Т. 18. — № 1. — С. 106–115. DOI: 10.29039/1992-6499-2023-1-106-115.5.5. Pachman L.M., Nolan B.E., DeRanieri D., Khojah A.M. Juvenile Dermatomyositis: New Clues to Diagnosis and Therapy // Current Treatment Options in Rheumatology. — 2021. — Vol. 7, № 1. — P. 39–62. — DOI: 10.1007/s40674-020-00168-5.6.6. Aguilar-Vazquez A, Chavarria-Avila E, Pizano-Martinez O et al. Geographical Latitude Remains as an Important Factor for the Prevalence of Some Myositis Autoantibodies: A Systematic Review // Front Immunol. — 2021. — Vol. 12. — Art. 672008. — DOI: 10.3389/fimmu.2021.672008.7.7. Kwiatkowska D., Reich A. The Significance of Autoantibodies in Juvenile Dermatomyositis // Biomed Research International. — 2021. — Vol. 2021. — Article ID 5513544. — DOI: 10.1155/2021/5513544.8.8. Li D., Tansley S. L. Juvenile Dermatomyositis-Clinical Phenotypes // Current Rheumatology Reports. — 2019. — Vol. 21, № 12. — Art. 74. — DOI: 10.1007/s11926-019-0871-4.