Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)1990-472XФедеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации1081110.18499/1990-472X-2025-26-1-110-114Markers of cell stress and endothelial dysfunction as components of diagnosis of type 2 diabetes mellitus and obesityLitvinovAlexeylitvin73008@gmail.comKrasnorutskayaOlgalech@vrngmu.ruDugushevaValeriasemikolenovaval@yandex.ruKotovaJuliakotova_u@inbox.ruBugrimovDaniilpatanat@vsmaburdenko.ruMorozovaAnnastrelnikova230504@gmail.comStrelnikovaSofiastrelnikova230504@gmail.com2803202526111011401042025Copyright © 2025, Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)2025<p>Introduction. This study focuses on the diagnostic role of markers of cellular stress and endothelial dysfunction in patients with type 2 diabetes mellitus and obesity. Cellular stress and endothelial dysfunction are key pathophysiological mechanisms that contribute to the progression of these diseases. We analyzed the general block (gender, age), anthropometric block (height, weight, BMI, waist circumference, fat mass, fat percentage, free fat mass, total, amount of water), anamnestic block (the fact of coronary heart disease onset, the time of coronary heart disease onset, the duration of diabetes mellitus, the fact of smoking), lipid profile data were taken into account (total cholesterol, HDL, LDL, TG), analyzed the level of various biomarkers associated with cellular stress (HSP70, HSP27) and the state of the endothelium (endothelin, stable metabolites of NO, ADMA, hs-CRP) in a group of patients with diabetes and obesity, with diabetes, in the control group. The findings of the study emphasize the importance of assessing markers of cellular stress and endothelial dysfunction as potential diagnostic tools for early diagnosis and monitoring of the condition of patients with type 2 diabetes mellitus and obesity. These findings may facilitate the development of more targeted strategies for the treatment and prevention of cardiovascular disease in this patient group.</p>diabetes mellitus type 2markers of cellular stressendothelial dysfunction, obesity.сахарный диабет 2-го типамаркеры клеточного стрессаэндотелиальная дисфункция, ожирение.1.1. Эргашева Г. Т. Исследование Причин Связи Диабета 2 Типа И Ожирения //Research Journal of Trauma and Disability Studies. – 2023. – Т. 2. – №. 12. – С. 305-311.2.2. Эргашева Г. Т. Сосуществование диабета 2 типа и сердечно-сосудистых заболеваний у пациентов //образование наука и инновационные идеи в мире. – 2024. – Т. 38. – №. 7. – С. 219-226.3.3. Покровская Е. В., Шестакова Е. А., Шестакова М. В. Эндотелиальная дисфункция у лиц с ожирением при наличии и отсутствии сахарного диабета 2 типа: оценка специфических маркеров //Сахарный диабет. – 2023. – Т. 26. – №. 5. – С. 439-445.4.4. Snider A. P., Wood J. R. Obesity induces ovarian inflammation and reduces oocyte quality // Reproduction. 2019. Vol. 158, No. 3. P. R79-R90. doi: 10.1530/REP-18-0583. PMID: 30999278.5.5. Xu S., Ilyas I., Little P. J., Li H., Kamato D., Zheng X., Luo S., Li Z., Liu P., Han J., Harding I. C., Ebong E. E., Cameron S. J., Stewart A. G., Weng J. Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies // Pharmacol Rev. 2021. Jul; 73(3): 924-967. doi: 10.1124/pharmrev.120.000096. PMID: 34088867.6.6. Medina-Leyte D. J., Zepeda-García O., Domínguez-Pérez M., González-Garrido A., Villarreal-Molina T., Jacobo-Albavera L. Endothelial dysfunction, inflammation and coronary artery disease: potential biomarkers and promising therapeutical approaches // Int. J. Mol. Sci. 2021. Apr 8; 22(8): 3850. doi: 10.3390/ijms22083850. PMID: 33917744; PMCID: PMC8068178.7.7. Moreira A.G., Kamat D. Personalized medicine // Pediatr Ann. 2022. Oct; 51(10): e379-e380. doi: 10.3928/19382359-20220803-02. Epub 2022 Oct 1. PMID: 36215091.8.8. Шляхто Е. В., Конради А. О. Персонализированная медицина. История, современное состояние проблемы и перспективы внедрения //Российский журнал персонализированной медицины. – 2021. – Т. 1. – №. 1. – С. 6-20.9.9. An Y., Xu B.T., Wan S.R., Ma X.M., Long Y., Xu Y., Jiang Z.Z. The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction // Cardiovasc Diabetol. 2023. Sep 2; 22(1): 237. doi: 10.1186/s12933-023-01965-7. PMID: 37660030; PMCID: PMC10475205.10.10. Ruze R., Liu T., Zou X., Song J., Chen Y., Xu R., Yin X., Xu Q. Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments // Front Endocrinol (Lausanne). 2023. Apr 21; 14:1161521. doi: 10.3389/fendo.2023.1161521. PMID: 37152942; PMCID: PMC10161731.