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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)</journal-id><journal-title-group><journal-title>Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)</journal-title></journal-title-group><issn publication-format="electronic">1990-472X</issn><publisher><publisher-name>Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">10807</article-id><article-id pub-id-type="doi">10.18499/1990-472X-2025-26-1-86-93</article-id><article-categories><subj-group subj-group-type="heading"><subject></subject></subj-group></article-categories><title-group><article-title>GASTRITIS, GASTROESOPHAGEAL REFLUX DISEASE, AND CONSTIPATION: AN OVERLAP SYNDROME?</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Shuklina</surname><given-names>Xenia</given-names></name><email>ksenya.zhukova.72@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Chichuga</surname><given-names>Ekaterina</given-names></name><email>kagorka@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Zazulina</surname><given-names>Olga</given-names></name><email>zazulina1953@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Gurovich</surname><given-names>Olga</given-names></name><email>olgavicg@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1"></aff><pub-date date-type="epub" iso-8601-date="2025-03-28" publication-format="electronic"><day>28</day><month>03</month><year>2025</year></pub-date><volume>26</volume><issue>1</issue><fpage>86</fpage><lpage>93</lpage><history><pub-date date-type="received" iso-8601-date="2025-04-01"><day>01</day><month>04</month><year>2025</year></pub-date></history><permissions><copyright-statement>Copyright © 2025, Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ)</copyright-statement><copyright-year>2025</copyright-year></permissions><abstract>&lt;p&gt;Overlap syndrome is a common occurrence in gastroenterological practice. The aim of this study was to determine the prevalence of overlap syndrome in children with gastritis and gastroduodenitis and to evaluate its clinical manifestations. A total of 100 children with chronic gastritis or gastroduodenitis treated in the gastroenterology department of the Regional Children's Clinical Hospital No. 1 were examined. Half of the children with chronic gastritis or gastroduodenitis also had gastroesophageal reflux disease (GERD), and 35% exhibited a combination of chronic gastritis/gastroduodenitis, GERD, and functional constipation. Clinical manifestations in such cases were similar: almost all children (98.0%) experienced pain syndrome. The typical GERD symptom of "heartburn" was more common in children with GERD (48%), though it was also reported in 34% of children without GERD. Constipation was associated with symptoms such as bloating and abdominal rumbling (78.0%, p=0.00001 and 71.0%, p=0.001, respectively).&lt;/p&gt;</abstract><kwd-group xml:lang="en"><kwd>gastroesophageal reflux disease, gastritis, constipation, overlap syndrome, children</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гастроэзофагеальная рефлюксная болезнь, гастрит, запор, синдром перекреста, дети.</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Friedman C., Sarantos G., Katz S., Geisler S. Understanding gastroesophageal reflux disease in children. JAAPA. 2021 Feb 1;34(2):12-18. doi: 10.1097/01.JAA.0000731488.99461.39. PMID: 33448710.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2. Бавыкина И.А., Петрова И.В., Бавыкин Д.В. 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